Project description DEENESFRITPL Towards innovative therapies against type 1 diabetes Type 1 diabetes (T1D) is an autoimmune disorder associated with the destruction of pancreatic islet beta cells, leading to little or no insulin production. The EU-funded INNODIA HARVEST project is undertaken by a large network of experts that aim to prevent or arrest T1D through innovative strategies. The project builds on the strong foundations of the INNODIA consortium, its origin. Partners will perform a series of intervention trials to study the mechanisms of T1D, identify biomarkers and study pathways associated with disease pathobiology. Through a beta-cell focussed and an immune-focussed intervention trial, the team hopes to deliver key knowledge for new combination therapies and to establish discovery pipelines for future T1D therapeutics. The people living with T1D remain at the center of INNODIA HARVEST, driving the implementation of patient-centered results, shaping our clinical trials and making meaningful change in the disease perspective. Show the project objective Hide the project objective Objective Building on the strong foundations of INNODIA, with its unique, Europe-wide clinical and basic research network for the study of type 1 diabetes (T1D), we propose in INNODIA HARVEST an ambitious program which aims to prevent and arrest T1D via focused objectives targeting consolidation and innovation. First, we will consolidate the INNODIA clinical network as the reference point for conducting studies to prevent or arrest T1D. We will transform our standardized clinical and bioresource platforms into a high-performance clinical trial network, running academic and industry-driven trials alongside small, mechanism-centric, biomarker-rich intervention trials to examine pathobiological pathways to T1D. INNODIA HARVEST will conduct two large studies to arrest T1D at its onset, one academia-driven, beta-cell focused (VER-A-T1D, verapamil) and one industry-driven, immune-focused (Iscalimab-study). We will exploit our original INNODIA Master Protocol allowing novel adaptive trial design to introduce combination therapies that build on complementary mechanisms. Second, we will extend our study design strategy by introducing novel biomarkers, both clinical (continuous glucose monitoring) and experimental (microbiome analysis) to deconvolute disease heterogeneity and identify new endpoints to accelerate identification of effective therapeutics. Third, we will use ‘disruptors’ in small mechanistic studies to channel innovation from clinic to basic research through a reverse immunology and reverse beta-cell biology approach. Finally, we will implement new discovery pipelines for future therapeutics, exploiting tools such as iPSC-derived islet-like cells to promote next generation target identification and drug development. As in INNODIA, the voice of people living with T1D and their families will hold a central place in INNODIA HARVEST to drive implementation of new, patient-proximal outcomes, shape our clinical trials, and bring about a meaningful change in disease perspective.A major objective of INNODIA Harvest is the execution of at least two new phase 2 trials (studying Verapamil (VER-A-T1D) or Iscalimab (CCFZ533X2207)). Considering the expected time to first patient-in as preparations for trial start can only be initiated after the start of the Action and possible fluctuating recruiting rates, due to the intercurrent COVID epidemic, there is a risk that INNODIA HARVEST will not be able to completely finalize the clinical trials, fully analyse the biomarkers collected and publish the results in the initially proposed 24 months duration. To ensure the finalization of the clinical trials and corresponding full execution of the given budget including eligibility of EFPIA in-kind contribution we propose to extend the duration of the Action from 24 to 36 months. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologytissue engineeringartificial pancreascontinuous glucose monitorsnatural sciencesbiological sciencesmicrobiology Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.7. - Innovative Medicines Initiative 2 (IMI2) Topic(s) IMI2-2019-19-01 - Restricted Call to maximise impact of IMI2 JU objectives and scientific priorities Call for proposal H2020-JTI-IMI2-2019-19-single-stage See other projects for this call Funding Scheme RIA - Research and Innovation action Coordinator KATHOLIEKE UNIVERSITEIT LEUVEN Net EU contribution € 666 502,50 Address Oude markt 13 3000 Leuven Belgium See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 1 719 667,06 Participants (40) Sort alphabetically Sort by Net EU contribution Expand all Collapse all THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE GB Net EU contribution € 427 500,00 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 405 250,00 MEDIZINISCHE UNIVERSITAT GRAZ Austria Net EU contribution € 740 570,00 Address Neue stiftingtalstrasse 6 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 725 683,00 UNIVERSITE LIBRE DE BRUXELLES Belgium Net EU contribution € 636 875,00 Address Avenue franklin roosevelt 50 1050 Bruxelles See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 18 500,00 KOBENHAVNS UNIVERSITET Denmark Net EU contribution € 155 950,00 Address Norregade 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 107 800,00 REGION HOVEDSTADEN Denmark Net EU contribution € 127 500,00 Address Kongens vaenge 2 3400 Hillerod See on map Region Danmark Hovedstaden Nordsjælland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Net EU contribution € 302 500,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 53 225,00 HELSINGIN YLIOPISTO Finland Net EU contribution € 425 310,00 Address Yliopistonkatu 3 00014 Helsingin yliopisto See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 245 190,00 OULUN YLIOPISTO Finland Net EU contribution € 63 750,00 Address Pentti kaiteran katu 1 90014 Oulu See on map Region Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 TURUN YLIOPISTO Finland Net EU contribution € 277 500,00 Address Yliopistonmaki 20014 Turku See on map Region Manner-Suomi Etelä-Suomi Varsinais-Suomi Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 HANNOVERSCHE KINDERHEILANSTALT Germany Net EU contribution € 186 000,00 Address Janusz korczak allee 12 30173 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 73 500,00 HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Germany Net EU contribution € 51 250,00 Address Ingolstadter landstrasse 1 85764 Neuherberg See on map Region Bayern Oberbayern München, Landkreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 TECHNISCHE UNIVERSITAET DRESDEN Germany Net EU contribution € 253 750,00 Address Helmholtzstrasse 10 01069 Dresden See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITAET ULM Germany Net EU contribution € 38 750,00 Address Helmholtzstrasse 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 15 125,00 UNIVERSITA DEGLI STUDI DI SIENA Italy Net EU contribution € 188 750,00 Address Via banchi di sotto 55 53100 Siena See on map Region Centro (IT) Toscana Siena Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 36 850,00 UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA Italy Net EU contribution € 0,00 Address Via dei vestini 31 66013 Chieti See on map Region Sud Abruzzo Chieti Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 UNIVERSITA DI PISA Italy Net EU contribution € 126 250,00 Address Lungarno pacinotti 43/44 56126 Pisa See on map Region Centro (IT) Toscana Pisa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CENTRE HOSPITALIER DE LUXEMBOURG Luxembourg Net EU contribution € 138 750,00 Address Rue nicolas ernest barble 4 1210 Luxembourg See on map Region Luxembourg Luxembourg Luxembourg Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE UNIVERSITY OF EXETER GB Net EU contribution € 63 750,00 Address The queen's drive northcote house EX4 4QJ Exeter See on map Region South West (England) Devon Devon CC Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH Poland Net EU contribution € 63 750,00 Address Ul. poniatowskiego 15 40 055 Katowice See on map Region Makroregion południowy Śląskie Katowicki Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 33 275,00 UNIVERZA V LJUBLJANI Slovenia Net EU contribution € 76 250,00 Address Kongresni trg 12 1000 Ljubljana See on map Region Slovenija Zahodna Slovenija Osrednjeslovenska Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 2 100,00 UNIVERSITE DE LAUSANNE Participation ended Switzerland Net EU contribution € 0,00 Address Quartier unil-centre bâtiment unicentre 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STICHTING RADBOUD UNIVERSITEIT Participation ended Netherlands Net EU contribution € 0,00 Address Houtlaan 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ACADEMISCH ZIEKENHUIS LEIDEN Netherlands Net EU contribution € 252 500,00 Address Albinusdreef 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 22 000,00 KING'S COLLEGE LONDON GB Net EU contribution € 238 750,00 Address Strand WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 885 526,00 LUNDS UNIVERSITET Sweden Net EU contribution € 63 750,00 Address Paradisgatan 5c 22100 Lund See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 26 625,00 HUMAN CELL DESIGN France Net EU contribution € 38 750,00 Address Place pierre potier centre pierre potier canceropole entree b 1 31000 Toulouse See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Occitanie Midi-Pyrénées Haute-Garonne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 SANOFI-AVENTIS DEUTSCHLAND GMBH Germany Net EU contribution € 0,00 Address Bruningstrasse 50 65929 Frankfurt am main See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 NOVO NORDISK A/S Denmark Net EU contribution € 0,00 Address Novo alle 1 2880 Bagsvaerd See on map Region Danmark Hovedstaden Københavns omegn Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 200 000,00 GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. GB Net EU contribution € 0,00 Address Great west road 980 TW89GS Brentford See on map Region London Outer London — West and North West Hounslow and Richmond upon Thames Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 ELI LILLY AND COMPANY LTD GB Net EU contribution € 0,00 Address Lilly house basingview RG21 4FA Basingstoke See on map Region South East (England) Hampshire and Isle of Wight North Hampshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 18 000,00 JDRF INTERNATIONAL United States Net EU contribution € 0,00 Address 26 broadway 14th floor 10004 New york See on map Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 45 610,00 THE LEONA M. AND HARRY B. HELMSLEY CHARITABLE TRUST United States Net EU contribution € 0,00 Address 230 park avenue suite 659 10169 New york See on map Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 18 179,00 OSLO UNIVERSITETSSYKEHUS HF Norway Net EU contribution € 63 750,00 Address Kirkeveien 166 tarnbygget 0450 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD GB Net EU contribution € 88 750,00 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 CARDIFF UNIVERSITY GB Net EU contribution € 104 947,50 Address Newport road 30 36 CF24 0DE Cardiff See on map Region Wales East Wales Cardiff and Vale of Glamorgan Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 272 375,00 UNIVERSITA VITA-SALUTE SAN RAFFAELE Italy Net EU contribution € 63 750,00 Address Via olgettina 58 20132 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 19 975,00 NOVARTIS PHARMA AG Switzerland Net EU contribution € 0,00 Address Lichtstrasse 35 4056 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 1 540 000,00 IMCYSE SA Belgium Net EU contribution € 0,00 Address Avenue du pre aily 41 4032 Sart tilman See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Région wallonne Prov. Liège Arr. Liège Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 517 800,00 OSPEDALE PEDIATRICO BAMBINO GESU Italy Net EU contribution € 1 250,00 Address Piazza sant onofrio 4 00165 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM Netherlands Net EU contribution € 71 650,00 Address Geert grooteplein 10 zuid 6525 GA Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 401 725,00