Structural and mechanistic basis of MICAL regulation

Project description

Mechanistic insight into the regulation of MICAL signalling

MICAL enzymes are fundamental for many cytoskeleton-driven processes including axon guidance, cell morphology, synaptogenesis and neuronal plasticity. They directly bind to actin filaments and participate in their dynamic disassembly. The scope of the EU-funded MICAL project is to understand the molecular mechanisms underlying MICAL signalling with particular emphasis on their activation and autoinhibition. Using state-of-the-art methodologies, scientists will elucidate the high-resolution structure of MICAL as well as other proteins, revealing important information on their molecular interactions. The project's results will unveil new possibilities in the manipulation of MICAL-driven signalling and help develop novel treatments for neurological disorders.

Fields of science

• natural sciences › biological sciences › neurobiology
• natural sciences › biological sciences › cell biology › cell signaling
• natural sciences › earth and related environmental sciences › geology › mineralogy › crystallography
• medical and health sciences › basic medicine › neurology
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes

Programme(s)

• H2020-EU.4. - SPREADING EXCELLENCE AND WIDENING PARTICIPATION

Topic(s)

• WF-02-2019 - Widening Fellowships

Call for proposal

H2020-WF-02-2019
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

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Coordinator

UNIVERZITA KARLOVA

Address

Ovocny Trh 560/5
116 36 Praha 1
Czechia

Activity type

Higher or Secondary Education Establishments

Links

EU contribution

€ 156 980,64