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Anchored Muscle cELls for IncontinencE

Project description

A targeted regenerative approach for treating incontinence

Faecal incontinence (FI) is the inability to control bowel movement, causing leakage of faeces. The EU-funded AMELIE project comprises a highly interdisciplinary consortium of experts who are proposing a novel regenerative intervention using autologous skeletal muscle derived cells (ASMDC) to restore the function of the sphincter muscle. Scientists will attach ASMDC to implantable microcarriers to improve cell delivery and engraftment in patients with FI. This will be tested in a randomised clinical trial. The strategy is expected to improve cell viability and increase the likelihood of muscle regeneration, contributing to improved continence.

Field of science

  • /medical and health sciences/clinical medicine/obstetrics and gynaecology/obstetrics/childbirth
  • /natural sciences/biological sciences

Call for proposal

H2020-SC1-2019-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITY COLLEGE LONDON
Address
Gower Street
WC1E 6BT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 4 488 266,11

Participants (12)

INSTITUTO SUPERIOR TECNICO
Portugal
EU contribution
€ 452 360
Address
Avenida Rovisco Pais 1
1049-001 Lisboa
Activity type
Higher or Secondary Education Establishments
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 1 129 739,53
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
EU contribution
€ 105 440
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
AARHUS UNIVERSITETSHOSPITAL
Denmark
EU contribution
€ 88 005
Address
Palle Juul-jensens Boulevard 99
8200 Aarhus
Activity type
Research Organisations
AARHUS UNIVERSITET
Denmark
EU contribution
€ 17 432,98
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN
France
EU contribution
€ 99 758,25
Address
Rue De Germont 1
76031 Rouen
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITATSKLINIKUM ERLANGEN
Germany
EU contribution
€ 114 843,75
Address
Maximiliansplatz 2
91054 Erlangen
Activity type
Higher or Secondary Education Establishments
INSTITUTO INVESTIGACION SANITARIA FUNDACION JIMENEZ DIAZ
Spain
EU contribution
€ 345 775
Address
Avenida De Los Reyes Catolicos 2
28040 Madrid
Activity type
Research Organisations
NHS BLOOD AND TRANSPLANT
United Kingdom
EU contribution
€ 1 374 064,13
Address
Oak House Reeds Crescent
WD24 4QN Watford
Activity type
Research Organisations
TTOPSTART BV
Netherlands
EU contribution
€ 180 750
Address
Euclideslaan 1
3584 BL Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BOWEL RESEARCH UK
United Kingdom
EU contribution
€ 331 775
Address
1St Floor Abernethy Building 2 Newark Street
E1 2AT London
Activity type
Research Organisations
CONSORZIO PER VALUTAZIONI BIOLOGICHE E FARMACOLOGICHE
Italy
EU contribution
€ 797 887,50
Address
Via Nicolo Putignani 178
70122 Bari
Activity type
Research Organisations