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MYB rearrangements in Adenoid Cystic Carcinoma: protagonists or secondary characters?

Project description

The role of MYB rearrangements in cancer

Adenoid cystic carcinoma (ACC) is a rare cancer with varying clinical behaviour depending on primary tumour site. ACCs harbour rearrangements of the MYB gene family of transcription factors resulting from chromosomal translocations. The scope of the EU-funded SALMYB project is to identify the cells that carry MYB rearrangements, elucidate their function and develop MYB-targeted therapies. Using state-of-the-art methods in molecular and cellular biology as well as genetic and tissue engineering, scientists will decipher the impact of MYB rearrangements on cell morphology, differentiation, proliferation, migration and invasion. The project's results will extend to other malignancies bearing MYB aberrations.

Coordinator

THE UNIVERSITY OF SHEFFIELD
Net EU contribution
€ 212 933,76
Address
Firth Court Western Bank
S10 2TN Sheffield
United Kingdom

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Region
Yorkshire and the Humber South Yorkshire Sheffield
Activity type
Higher or Secondary Education Establishments
Other funding
€ 212 933,76