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Bottom up biophysics approach to resolve the looping structure of chromosomes

Project description

Interconnection of spatial chromosome structure and function

The spatial structure of the genome is critical for its biological function. The goal of the EU-funded LoopingDNA project is to understand the fundamental interconnection of structure and function of chromosomes using a biophysics approach. Research will focus on structural maintenance of chromosomes' (SMC) protein complexes, ring-shaped proteins that create large loops of DNA thought to be the basis of chromosome structure. The experiments will help answer open questions of how SMCs handle natural chromosomal fibres loaded with DNA-binding proteins and regulate gene expression. The researchers will even aim to build a chromosome from the bottom up, using a ‘genome-in-a-box’ approach, where a genome-length bare DNA is added SMC protein complexes and other DNA-processing proteins. This unique bottom-up approach may generate a radically new understanding of the physical forces and protein systems that shape chromosomes.

Call for proposal

ERC-2019-ADG
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Funding Scheme

ERC-ADG - Advanced Grant

Host institution

TECHNISCHE UNIVERSITEIT DELFT
Address
Stevinweg 1
2628 CN Delft
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 500 000

Beneficiaries (1)

TECHNISCHE UNIVERSITEIT DELFT
Netherlands
EU contribution
€ 2 500 000
Address
Stevinweg 1
2628 CN Delft
Activity type
Higher or Secondary Education Establishments