Complement factor H-related proteins and their role in pathogenesis
Complement factor H (FH) and FH-related (FHR) proteins are associated with systemic and organ-specific pathologies including impaired defense against infections and incurable renal, eye and autoimmune diseases. While the biological function of FH is well-defined, the function of the other six highly homologous FHR proteins is mostly unknown, as is their role in the disease-specific pathogenic mechanisms. The EU-funded SciFiMed project will study the FH family proteins' contributions in health and disease aiming to obtain proof-of-principle for a multiplex detection system to simultaneously quantify and analyse the functional activity of all seven proteins in patient samples. This high-impact project will enable new product developments and provide new perspectives for patient treatments.
Fields of science
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Funding SchemeRIA - Research and Innovation action