CORDIS
EU research results

CORDIS

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General-purpose virus-neutralizing engulfing shells with modular target-specificity

Project information

Grant agreement ID: 899619

Status

Ongoing project

  • Start date

    1 June 2020

  • End date

    31 May 2024

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 3 880 942,50

  • EU contribution

    € 3 880 942,50

Coordinated by:

TECHNISCHE UNIVERSITAET MUENCHEN

Germany

Objective

Viral infections affect millions of people every year and cause tremendous human suffering and costs to society. For approximately 70% of all WHO listed viruses, no treatment is available and the antiviral drugs that do exist typically must be applied very early after infection to be effective. The VIROFIGHT consortium proposes a radically new approach to fight viral infections, to help reduce the scale and sheer impact of viral infections, to address the problem of a lack of broadly applicable antiviral treatments, and to create means for combating emerging pathogens. Instead of targeting virus-specific proteins or enzymes by small molecules as current antivirals do, we will construct synthetic nano-shells that can specifically recognize and engulf entire viruses to efficiently neutralize the pathogen by occlusion. To achieve this technological target, our interdisciplinary project integrates supramolecular chemistry, molecular nanoengineering, and virology with the mission to develop and test prototypes of engulfing nano-shells that have the principal capacity to neutralize any given virus. We will fabricate biocompatible nano-shells through DNA origami and protein design and attach modularly virus-specific molecules to them in a multivalent fashion, to exploit avidity effects for strong virus binding. The virus binders will be identified through rapid in vitro selection processes designed to be applicable to any target virus. Neutralization assays will be used to test our concept on a variety of viruses. VIROFIGHT has the potential to attain revolutionary properties: shell prototypes can be developed and produced in the course of weeks after discovery of a viral pathogen, and the drug concept can be used and adapted for a wide variety of viral pathogens, without having detailed knowledge about the virus. The VIROFIGHT concept aimed at eradicating multiple viruses thus has great potential for decreasing the burden for patients and saving costs to society.

Coordinator

TECHNISCHE UNIVERSITAET MUENCHEN

Address

Arcisstrasse 21
80333 Muenchen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 642 882,36

Participants (4)

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 648 450

KEMIJSKI INSTITUT

Slovenia

EU Contribution

€ 630 957,50

UNIVERSITAET REGENSBURG

Germany

EU Contribution

€ 686 437,50

ARTTIC

France

EU Contribution

€ 272 215,14

Project information

Grant agreement ID: 899619

Status

Ongoing project

  • Start date

    1 June 2020

  • End date

    31 May 2024

Funded under:

H2020-EU.1.2.1.

  • Overall budget:

    € 3 880 942,50

  • EU contribution

    € 3 880 942,50

Coordinated by:

TECHNISCHE UNIVERSITAET MUENCHEN

Germany