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Using cell-cell interactions to unlock new cancer treatments: Forcing neural crest tumors back onto the developmental path

Project description

Forced differentiation of tumour cells as a new cancer treatment

The interactions between tumours and the microenvironment are often critical to uncovering the mechanisms of their survival. The alternative approach to killing tumour cells, either directly or through the immune system, is to force them to differentiate. This strategy is particularly promising for tumours originated from the progenitor populations that failed to follow proper differentiation cascades. The EU-funded KILL-OR-DIFFERENTIAT project will develop a systematic approach for the characterisation of the cell–cell interactions in complex microenvironments, applying analysis of disassociated single-cell transcriptomics to identify intercellular pathways that can push tumours of neural crest origin towards terminal differentiation.

Host institution

MEDIZINISCHE UNIVERSITAET WIEN
Net EU contribution
€ 2 454 980,00
Address
Spitalgasse 23
1090 Wien
Austria

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (6)

MEDIZINISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 2 454 980,00
Address
Spitalgasse 23
1090 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 1 712 500,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

INSTITUT CURIE
France
Net EU contribution
€ 312 500,00
Address
Rue D'ulm 26
75231 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 2 572 441,00
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC.
United States
Net EU contribution
€ 238 615,00
Address
Office Of The General Counsel, Holyoke Center, Suite 980, Massachusetts Avenue 1350
02138 Cambridge

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Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

PRESIDENT AND FELLOWS OF HARVARD COLLEGE
United States
Net EU contribution
€ 2 086 115,00
Address
Massachusetts Avenue 1350
02138 Cambridge

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Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00