Forced differentiation of tumour cells as a new cancer treatment
The interactions between tumours and the microenvironment are often critical to uncovering the mechanisms of their survival. The alternative approach to killing tumour cells, either directly or through the immune system, is to force them to differentiate. This strategy is particularly promising for tumours originated from the progenitor populations that failed to follow proper differentiation cascades. The EU-funded KILL-OR-DIFFERENTIAT project will develop a systematic approach for the characterisation of the cell–cell interactions in complex microenvironments, applying analysis of disassociated single-cell transcriptomics to identify intercellular pathways that can push tumours of neural crest origin towards terminal differentiation.
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Funding SchemeERC-SyG - Synergy grant