Skip to main content

Using cell-cell interactions to unlock new cancer treatments: Forcing neural crest tumors back onto the developmental path

Project description

Forced differentiation of tumour cells as a new cancer treatment

The interactions between tumours and the microenvironment are often critical to uncovering the mechanisms of their survival. The alternative approach to killing tumour cells, either directly or through the immune system, is to force them to differentiate. This strategy is particularly promising for tumours originated from the progenitor populations that failed to follow proper differentiation cascades. The EU-funded KILL-OR-DIFFERENTIAT project will develop a systematic approach for the characterisation of the cell–cell interactions in complex microenvironments, applying analysis of disassociated single-cell transcriptomics to identify intercellular pathways that can push tumours of neural crest origin towards terminal differentiation.

Call for proposal

ERC-2019-SyG
See other projects for this call

Funding Scheme

ERC-SyG - Synergy grant

Host institution

MEDIZINISCHE UNIVERSITAET WIEN
Address
Spitalgasse 23
1090 Wien
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 454 980

Beneficiaries (4)

MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 2 454 980
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 2 025 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 2 572 441
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC.
United States
EU contribution
€ 2 324 730
Address
Office Of The General Counsel, Holyoke Center, Suite 980, Massachusetts Avenue 1350
02138 Cambridge
Activity type
Research Organisations