Studying top-down interactions at different biological scales
At different biological scales, new properties in form and function often have an impact on proteins, DNA and RNA, the lower-scale components of the central dogma of biology. It is important to quantify these top-down effects to predict and understand the complexity of cell fate determination. To address this, the EU-funded CROSSINGSCALES project will apply quantitative imaging and genome-wide transcriptomics on stem cell cultures and early zebrafish embryos. Results will create a holistic view of nuclear and chromatin states, gene expression, subcellular organisation and tissue-scale organisation across millions of individual cells. The project will contribute towards the understanding of the dynamic, spatiotemporally controlled interaction of gene expression and cellular signalling that drive life as we know it.
Fields of science
Call for proposal
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