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Reverse Scale-Crossing Effects In Biology

Project description

Studying top-down interactions at different biological scales

At different biological scales, new properties in form and function often have an impact on proteins, DNA and RNA, the lower-scale components of the central dogma of biology. It is important to quantify these top-down effects to predict and understand the complexity of cell fate determination. To address this, the EU-funded CROSSINGSCALES project will apply quantitative imaging and genome-wide transcriptomics on stem cell cultures and early zebrafish embryos. Results will create a holistic view of nuclear and chromatin states, gene expression, subcellular organisation and tissue-scale organisation across millions of individual cells. The project will contribute towards the understanding of the dynamic, spatiotemporally controlled interaction of gene expression and cellular signalling that drive life as we know it.

Call for proposal

ERC-2019-ADG
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Funding Scheme

ERC-ADG - Advanced Grant

Host institution

UNIVERSITAT ZURICH
Address
Ramistrasse 71
8006 Zurich
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 411 075

Beneficiaries (1)

UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 2 411 075
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments