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Deciphering the unconventional receptor binding and modulation activity of bat influenza A viruses

Project description

Understanding influenza virus tropism

It has long been thought that avian hosts are the primary reservoir for all influenza A viruses (IAVs). This is now being challenged by the identification of two novel IAV subtypes in bats: H17N10 and H18N11. Despite an otherwise high degree of functional homology to conventional IAVs, the surface proteins of bat IAVs demonstrate several unprecedented characteristics. The ERC-funded Bat Flu project will improve our understanding of influenza virus tropism. Specifically, it will study the mode of interaction between H17/H18 and MHC-II and explore the mechanism of N10/N11-dependent downregulation of MHC-II. The Bat Flu project will also explore the plasticity of IAVs to use new cellular entry factors.

Host institution

UNIVERSITAETSKLINIKUM FREIBURG
Net EU contribution
€ 2 499 637,50
Address
Hugstetter Strasse 49
79106 Freiburg
Germany

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Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 499 637,50

Beneficiaries (1)

UNIVERSITAETSKLINIKUM FREIBURG
Germany
Net EU contribution
€ 2 499 637,50
Address
Hugstetter Strasse 49
79106 Freiburg

See on map

Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 499 637,50