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Cartilaginous tissue regeneration by non-viral gene therapy; taking the hurdles towards efficient delivery

Project description

Non-viral gene therapy for intervertebral disc degeneration

Intervertebral disc (IVD) degeneration is a main cause of chronic low back pain and osteoarthritis of the joints, affecting many individuals worldwide. To restore tissue health in affected patients, the EU-funded CARTHAGO project is working on a non-viral gene therapy approach based on the delivery of oligonucleotides and encoding nucleic acids. This strategy combined with ultrasound overcomes accessibility issues of cartilaginous tissues encountered by traditional drugs and enhances tissue penetration and transfection. The work will be carried out by early-stage researchers who will also acquire transferable skills for a career in the field.

Call for proposal

H2020-MSCA-ITN-2020
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 265 619,88

Participants (11)

UPPSALA UNIVERSITET
Sweden
EU contribution
€ 563 965,92
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA
Romania
EU contribution
€ 219 591,36
Address
Victor Babes Street 8
400012 Cluj-napoca
Activity type
Higher or Secondary Education Establishments
AARHUS UNIVERSITET
Denmark
EU contribution
€ 297 522
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
AALTO KORKEAKOULUSAATIO SR
Finland
EU contribution
€ 280 805,76
Address
Otakaari 1
02150 Espoo
Activity type
Higher or Secondary Education Establishments
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA
Portugal
EU contribution
€ 237 720,24
Address
Rua Alfredo Allen 208
4200 135 Porto
Activity type
Research Organisations
AO-FORSCHUNGSINSTITUT DAVOS
Switzerland
EU contribution
€ 562 553,28
Address
Clavadelerstrasse 8
7270 Davos Platz
Activity type
Research Organisations
UNIWERSYTET JAGIELLONSKI
Poland
EU contribution
€ 227 478,60
Address
Ul. Golebia 24
31007 Krakow
Activity type
Higher or Secondary Education Establishments
PERCUROS BV
Netherlands
EU contribution
€ 531 239,76
Address
Tarweveld 5
6617 CD Bergharen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Albumedix Ltd
United Kingdom
EU contribution
€ 303 172,56
Address
Castle Boulevard 59
NG7 1FD Nottingham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
20MED THERAPEUTICS BV
Netherlands
EU contribution
€ 265 619,88
Address
Drienerlolaan 5 Kamer Zh252
7522 NB Enschede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JENACELL GMBH
Germany
EU contribution
€ 252 788,40
Address
Goschwitzer Str. 22
07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)