Cartilaginous tissue regeneration by non-viral gene therapy; taking the hurdles towards efficient delivery

Project description

Non-viral gene therapy for intervertebral disc degeneration

Intervertebral disc (IVD) degeneration is a main cause of chronic low back pain and osteoarthritis of the joints, affecting many individuals worldwide. To restore tissue health in affected patients, the EU-funded CARTHAGO project is working on a non-viral gene therapy approach based on the delivery of oligonucleotides and encoding nucleic acids. This strategy combined with ultrasound overcomes accessibility issues of cartilaginous tissues encountered by traditional drugs and enhances tissue penetration and transfection. The work will be carried out by early-stage researchers who will also acquire transferable skills for a career in the field.

Fields of science

• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › biochemistry › biomolecules › nucleic acid

Programme(s)

• H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers

Topic(s)

• MSCA-ITN-2020 - Innovative Training Networks

Call for proposal

H2020-MSCA-ITN-2020
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Address

Heidelberglaan 100
3584 CX Utrecht
Netherlands

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 265 619,88

Participants (11)

UPPSALA UNIVERSITET

Sweden

EU contribution

€ 563 965,92

Address

Von Kraemers Alle 4
751 05 Uppsala

Activity type

Higher or Secondary Education Establishments

UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA

Romania

EU contribution

€ 219 591,36

Address

Victor Babes Street 8
400012 Cluj-napoca

Activity type

Higher or Secondary Education Establishments

AARHUS UNIVERSITET

Denmark

EU contribution

€ 297 522

Address

Nordre Ringgade 1
8000 Aarhus C

Activity type

Higher or Secondary Education Establishments

AALTO KORKEAKOULUSAATIO SR

Finland

EU contribution

€ 280 805,76

Address

Otakaari 1
02150 Espoo

Activity type

Higher or Secondary Education Establishments

INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA

Portugal

EU contribution

€ 237 720,24

Address

Rua Alfredo Allen 208
4200 135 Porto

Activity type

Research Organisations

AO-FORSCHUNGSINSTITUT DAVOS

Switzerland

EU contribution

€ 562 553,28

Address

Clavadelerstrasse 8
7270 Davos Platz

Activity type

Research Organisations

UNIWERSYTET JAGIELLONSKI

Poland

EU contribution

€ 227 478,60

Address

Ul. Golebia 24
31007 Krakow

Activity type

Higher or Secondary Education Establishments

PERCUROS BV

Netherlands

EU contribution

€ 531 239,76

Address

Tarweveld 5
6617 CD Bergharen

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Albumedix Ltd

United Kingdom

EU contribution

€ 303 172,56

Address

Castle Boulevard 59
NG7 1FD Nottingham

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

20MED THERAPEUTICS BV

Netherlands

EU contribution

€ 265 619,88

Address

Drienerlolaan 5 Kamer Zh252
7522 NB Enschede

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

JENACELL GMBH

Germany

EU contribution

€ 252 788,40

Address

Goschwitzer Str. 22
07745 Jena

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)