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Cartilaginous tissue regeneration by non-viral gene therapy; taking the hurdles towards efficient delivery

Project description

Non-viral gene therapy for intervertebral disc degeneration

Intervertebral disc (IVD) degeneration is a main cause of chronic low back pain and osteoarthritis of the joints, affecting many individuals worldwide. To restore tissue health in affected patients, the EU-funded CARTHAGO project is working on a non-viral gene therapy approach based on the delivery of oligonucleotides and encoding nucleic acids. This strategy combined with ultrasound overcomes accessibility issues of cartilaginous tissues encountered by traditional drugs and enhances tissue penetration and transfection. The work will be carried out by early-stage researchers who will also acquire transferable skills for a career in the field.

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Net EU contribution
€ 265 619,88
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (11)

UPPSALA UNIVERSITET
Sweden
Net EU contribution
€ 563 965,92
Address
Von Kraemers Alle 4
751 05 Uppsala

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Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA
Romania
Net EU contribution
€ 219 591,36
Address
Victor Babes Street 8
400012 Cluj-napoca

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Region
Macroregiunea Unu Nord-Vest Cluj
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AARHUS UNIVERSITET
Denmark
Net EU contribution
€ 595 044,00
Address
Nordre Ringgade 1
8000 Aarhus C

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Region
Danmark Midtjylland Østjylland
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AALTO KORKEAKOULUSAATIO SR
Finland
Net EU contribution
€ 280 805,76
Address
Otakaari 1
02150 Espoo

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA
Portugal
Net EU contribution
€ 237 720,24
Address
Rua Alfredo Allen 208
4200 135 Porto

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Region
Continente Norte Área Metropolitana do Porto
Activity type
Research Organisations
Non-EU contribution
€ 0,00
AO-FORSCHUNGSINSTITUT DAVOS
Switzerland
Net EU contribution
€ 562 553,28
Address
Clavadelerstrasse 8
7270 Davos Platz

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Region
Schweiz/Suisse/Svizzera Ostschweiz Graubünden / Grigioni / Grischun
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIWERSYTET JAGIELLONSKI
Poland
Net EU contribution
€ 227 478,60
Address
Ul. Golebia 24
31-007 Krakow

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Region
Makroregion południowy Małopolskie Miasto Kraków
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
PERCUROS BV
Netherlands
Net EU contribution
€ 531 239,76
Address
Eerbeeklaan 42
2573 HT 'S-gravenhage

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Albumedix Ltd

Participation ended

United Kingdom
Net EU contribution
€ 0,00
Address
Castle Boulevard 59
NG7 1FD Nottingham

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
East Midlands (England) Derbyshire and Nottinghamshire Nottingham
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
20MED THERAPEUTICS BV
Netherlands
Net EU contribution
€ 265 619,88
Address
Drienerlolaan 5 Kamer Zh252
7522 NB Enschede

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Overijssel Twente
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
JENACELL GMBH
Germany
Net EU contribution
€ 252 788,40
Address
Goschwitzer Str. 22
07745 Jena

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Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00