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Anti-Cancer Light-Controllable Antibody-Peptide Conjugates

Objective

Project ALISE (Antibody Light-Induced Selectivity Enhancement) will integrate the expertise, resources and knowledge of participating Institutions focusing on design, synthesis and preclinical study of conjugates of monoclonal antibodies with peptides whose anti-cancer activity can be enhanced in tumours by irradiation with light (LC-APCs). The possibility to boost the anti-cancer activity only in tumours, multiplied by targeting cancer cells by antibodies will be a basis for innovative and safer therapeutic strategies. Four of seven participating Institutions successfully collaborated in the field of light-controllable anticancer peptides, but this Project will widen the scope of collaboration, both in terms of the research field and collaborating Institutions. The participating Institutions are complementary in their expertise and know-how: the University of Cambridge will contribute with its know-how in design and preparation of antibodies. Light controllable peptides will be designed at Latvian Institute of Organic Synthesis and Karlsruhe Institute of Technology, synthesized, then loaded onto the antibodies in Cambridge. Company Enamine will perform initial screening of the conjugates in vitro and assess their safety. National Cancer Institute of Ukraine will contribute with its expertise in immunology, Cancer Center Amsterdam – with its expertise and knowledge in preclinical and clinical oncology. Lumobiotics GmbH will complement the consortium with its expertise in drug development. Integration of this potential will be achieved through research staff exchange and other activities organized in five work packages: 1) design and synthesis of novel light-controllable peptides as anti-cancer antibody payloads; 2) preparation and characterization of peptide conjugates with a model antibody; 3) biological screening of model LC-APCs; 4) preclinical evaluation of the LC-APCs aiming at treatment of human PDAC; 5) management, training, communication, dissemination.

Call for proposal

H2020-MSCA-RISE-2020
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE
Address
78 Chervonotkatska Str.
02094 Kyiv
Ukraine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 234 600

Participants (6)

KARLSRUHER INSTITUT FUER TECHNOLOGIE
Germany
EU contribution
€ 73 600
Address
Kaiserstrasse 12
76131 Karlsruhe
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 78 200
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
LATVIJAS ORGANISKAS SINTEZES INSTITUTS
Latvia
EU contribution
€ 55 200
Address
Aizkraukles 21
1006 Riga
Activity type
Research Organisations
NATIONAL CANCER INSTITUTE
Ukraine
EU contribution
€ 73 600
Address
33/43 Lomonosova Street
03022 Kiyv
Activity type
Research Organisations
LUMOBIOTICS GmbH
Germany
EU contribution
€ 165 600
Address
Auerstrasse 2
76227 Karlsruhe
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING VUMC
Netherlands
EU contribution
€ 64 400
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations