LEGO-based immunotherapics against cancer
Cancer incidence is rising globally, and despite advances in treatments, there are many side effects that hamper their effectiveness. Immunotherapy has emerged as a promising anticancer strategy, but efficacy and toxicity issues remain to be addressed. The EU-funded THERA-LEGO project will build on previous experience to produce antibody recruiting glycodendrimers (ARGs) using a molecular LEGO approach capable of binding endogenous antibodies and redirecting them against tumours. ARGs form ternary complexes with cancer cells, causing cell death. Scientists will screen these synthetic ARG structures in humanised models of cancer before proceeding with clinical development.
Call for proposal
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Funding SchemeERC-POC-LS - ERC Proof of Concept Lump Sum Pilot