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Commercial feasibility of a therapeutic approach to cancer based on ‘LEGO’ antibody recruiting glycodendrimers

Project description

LEGO-based immunotherapics against cancer

Cancer incidence is rising globally, and despite advances in treatments, there are many side effects that hamper their effectiveness. Immunotherapy has emerged as a promising anticancer strategy, but efficacy and toxicity issues remain to be addressed. The EU-funded THERA-LEGO project will build on previous experience to produce antibody recruiting glycodendrimers (ARGs) using a molecular LEGO approach capable of binding endogenous antibodies and redirecting them against tumours. ARGs form ternary complexes with cancer cells, causing cell death. Scientists will screen these synthetic ARG structures in humanised models of cancer before proceeding with clinical development.

Call for proposal

ERC-2020-PoC
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Host institution

UNIVERSITE GRENOBLE ALPES
Address
621 Avenue Centrale
38058 Grenoble
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 150 000

Beneficiaries (1)

UNIVERSITE GRENOBLE ALPES
France
EU contribution
€ 150 000
Address
621 Avenue Centrale
38058 Grenoble
Activity type
Higher or Secondary Education Establishments