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Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair

Objective

InterLynk aims to develop multi-tissue 3D patient-specific scaffolds by providing a portfolio of highly compatible and biofunctional composite inks and biomaterials, and streamlining their co-processing using an upgraded AM equipment. Unprecedented biofunctionality in the synthetic reconstruction of complex interfacial tissues is expected to be obtained. A double network photocrosslinkable biomaterial system based on human plasma-derived Platelet Lysates (PL) will be used as base matrix. The PL-based hydrogels will be further combined with mechanically reinforcing biomaterials, namely CaP-based bioceramics and PCL-LA polymers, to produce bone-like and fibrous structures, respectively, and will be able to be blended with natural drug carriers (flavonoid-loaded nanomicelles). Compositional and structural variations will be enabled by combining photo-assisted printing and MEW/ESP in a single-step hybrid AM process. New computational tools will support the mechanobiological optimization of all biomaterials and final parts, as well as the AM process design. Superior biofunctionality of the InterLynk’ scaffolds will be validated in an highly complex multi-tissue interfacial biosystem, the temporomandibular joint.
InterLynk will implement comprehensive strategies to engage key groups of stakeholders (clinical, engineering, regulatory and market-related) in the development of biological scaffolds, establishing a truly multidisciplinary co-creation process. These scaffolds are expected to have no counterpart in both fabrication and multi-tissue regeneration, avoiding time-consuming and costly procedures in both dimensions. This will increase current AM (bio)fabrication capabilities and application range, widely extending its use. Their high flexibility and unique performance will considerably reduce immune rejection, risk of contamination and, inherently, rehabilitation time of multi-tissue injuries resulting in increasing wellbeing and healthcare costs reduction.

Call for proposal

H2020-NMBP-TR-IND-2020-twostage
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Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSIDADE DE AVEIRO
Address
Campus Universitário De Santiago
3810-193 Aveiro
Portugal
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 630 865

Participants (7)

METATISSUE - BIOSOLUTIONS, LDA
Portugal
EU contribution
€ 799 836
Address
Pci Parque De Ciencia E Inovacao Edificio Central Via Do Conhecimento
3830-352 Ilhavo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INEGI - INSTITUTO DE CIENCIA E INOVACAO EM ENGENHARIA MECANICA E ENGENHARIA INDUSTRIAL
Portugal
EU contribution
€ 699 030
Address
Rua Dr Roberto Frias 400
4200 465 Porto
Activity type
Research Organisations
ENVISIONTEC GMBH
Germany
EU contribution
€ 400 000
Address
Brusseler Strasse
45968 Gladbeck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 799 695
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 1 090 215
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
KUROS BIOSCIENCES BV
Netherlands
EU contribution
€ 399 997
Address
Professor Bronkhorstlaan 10 G 48
3723 MB Bilthoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PROMOSCIENCE SRL
Italy
EU contribution
€ 180 000
Address
Localita Padriciano 99
34012 Trieste
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)