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Coherent Raman Imaging for the Molecular Study of the OrigiN of diseases

Objective

CRIMSON aims to provide a next-generation bio-photonics imaging device based on vibrational spectroscopy, with the potential to revolutionise the study of the cellular origin of diseases allowing for novel approaches towards personalised therapy. We will employ label-free broadband coherent Raman scattering (CRS) extended to the fingerprint region, in combination with artificial-intelligence spectroscopic data analysis, for fast cell/tissue classification with unprecedented biochemical sensitivity. We will develop a hyperspectral CRS microscope for 3D quantitative imaging of sub-cellular compartments in living cells and organoids. High acquisition speed will enable the observation of intra- and inter-cellular dynamic changes by time-lapse imaging. We will simulate future in-vivo studies and demonstrate the capability to image inside the body, realizing an innovative CRS endoscope and applying it to ex-vivo thick tissue slides. CRIMSON relies on the development of new compact ultrafast lasers, innovative broadband CRS detection schemes and advanced spectral analysis routines.
To validate the CRS platform, we will investigate three open biological questions related to cancer, as paradigmatic examples of the complexity and heterogeneity of cellular diseases. The results will have profound societal impacts, improving patients’ quality of life and reducing public healthcare costs.
CRIMSON brings together a multidisciplinary team of world-leading academic organizations, biomedical end users and innovative SMEs, with vertical integration of all required skills. CRIMSON will bridge the gap between research and product development, increasing the TRL and making CRS a user-friendly, robust and cost-effective mainstream tool for a vast biological research community. Commercial exploitation by the participating SMEs, including a biomedical equipment manufacturer, will create a competitive advantage in the European biophotonics-related market for microscopes and R&D tools.

Call for proposal

H2020-ICT-2020-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

POLITECNICO DI MILANO
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 016 287,50

Participants (9)

LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
Germany
EU contribution
€ 571 575
Address
Albert Einstein Strasse 9
07745 Jena
Activity type
Research Organisations
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 553 150
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI
Italy
EU contribution
€ 299 047,50
Address
Via Venezian 1
20133 Milan
Activity type
Research Organisations
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 555 740
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Universitätsklinikum Jena
Germany
EU contribution
€ 367 906,25
Address
Bachstraße 18
07743 Jena
Activity type
Higher or Secondary Education Establishments
ACTIVE FIBER SYSTEMS GMBH
Germany
EU contribution
€ 582 947,50
Address
Ernst Ruska Ring 17
07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LIGHTCORE TECHNOLOGIES
France
EU contribution
€ 404 085
Address
117 Traverse De La Montre
13011 Marseille
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CAMBRIDGE RAMAN IMAGING LTD
United Kingdom
EU contribution
€ 468 312,50
Address
Wellington House East Road
CB1 1BH Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
3RDPLACE SRL
Italy
EU contribution
€ 313 750
Address
Foro Buonaparte 71
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)