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Circular DNA-driven cancer genome remodeling

Project description

Understanding principles of neuroblastoma genome remodelling

Recent studies have revealed that cancer cells have the intrinsic ability to create and re-incorporate extrachromosomal circular DNAs. It has been shown that these genomic events are more frequent in primary human neuroblastomas, a childhood tumour, suggesting that DNA circularisation is a major driver of neuroblastoma genome remodelling. The EU-funded CancerCirculome aims to discover new principles of neuroblastoma genome remodelling, investigating the underlying mechanisms and functional consequences of extrachromosomal DNA circularisation and chromosomal re-integration. The uncovered principles will be applied to identify novel diagnostic and predictive markers for clinical risk assessment and neuroblastoma treatment.

Host institution

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Net EU contribution
€ 1 498 888,00
Address
Chariteplatz 1
10117 Berlin
Germany

See on map

Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 498 888,00

Beneficiaries (1)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
Net EU contribution
€ 1 498 888,00
Address
Chariteplatz 1
10117 Berlin

See on map

Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 498 888,00