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Improving the safety of live attenuated viral vaccines by exploiting RNA silencing pathways

Project description

Making vaccines for mosquito-transmitted viruses ever safer

Live-attenuated viral vaccines represent successful vaccine approaches but come with a risk of reversion or recombination of the vaccine to a virulent form. An important consideration for mosquito-transmitted viruses is that they should not replicate in mosquito vectors to prevent vaccine-derived virulent strains. The EU-funded VIVARNAsilencing2 proof-of-concept project aims to enhance the safety of live-attenuated vaccines for mosquito-transmitted viruses by preventing their replication in mosquitoes. The researchers will exploit a small RNA-based gene regulatory network of the mosquito vector to target viral RNA for degradation. The initial focus will be on the viruses with a large disease burden, such as the dengue virus, Zika virus and chikungunya virus.

Call for proposal

ERC-2020-PoC
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Host institution

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 150 000

Beneficiaries (2)

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
EU contribution
€ 150 000
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Activity type
Higher or Secondary Education Establishments
STICHTING RADBOUD UNIVERSITEIT

Participation ended

Netherlands
EU contribution
€ 0
Address
Houtlaan 4
6525 XZ Nijmegen
Activity type
Higher or Secondary Education Establishments