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Neuronal microscopy for cell behavioural examination and manipulation

Objective

The REVEAL project aims at installing a novel microscope at the interface of instrumentation, machine learning and Biology. This new microscopy technique will rely heavily on neural networks to be able to perceive, interpret, conjecture, infer, anticipate and act. The present project intends to lay down the foundations of this ‘neuronal microscopy’ in the realms of 2D and 3D cell live imaging.
To achieve this goal, we will develop the necessary tools and the first instruments that will demonstrate the feasibility and the power of this new microscopy framework. In particular, we will develop a ‘cell picking neuronal microscope’ that will allow us to detect and collect different subtype of liver cells that are due to become tumoral and analyse them ahead of tumour manifestation. This analysis will help us to characterize the cellular heterogeneity known to exist at the origin of liver cancer. It will provide a direct mapping between cellular phenotypes observed under microscope and gene expression present in the early stages of liver cancer. Overall, we are thus defining a novel methodology, giving a central place to neuronal microscopy in the understanding of the cellular origin of the diseases.
REVEAL is a multidisciplinary project engaging 7 EU partners (2 being SMEs) from 4 countries covering the RTO, academic and industrial worlds, including medical doctors. An implementation plan is presented in the form of 6 work packages, 4 of them being technical. Synergy in communication and dissemination by the several partners and stakeholders will permit to maximize the project impact. Solutions to overcome the technological barriers, as well as appropriate deliverables, tasks, milestones and risks are presented, in order to complete the project objectives in due time . The REVEAL project outcomes are fully in line with the H2020 ICT-36-2020 call, subtopic iv, as it will develop novel methods and devices as research tools to understand the cellular origin of diseases.

Call for proposal

H2020-ICT-2020-2
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Address
Rue Leblanc 25
75015 Paris 15
France
Activity type
Research Organisations
EU contribution
€ 1 829 606,25

Participants (6)

IPRASENSE
France
EU contribution
€ 298 750
Address
Avenue De L'europe Cap Alpha
34830 Clapiers
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ECOLE NORMALE SUPERIEURE DE LYON
France
EU contribution
€ 1 618 806
Address
Parvis Rene Descartes 15
69342 Lyon
Activity type
Higher or Secondary Education Establishments
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 450 468,75
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO
Italy
EU contribution
€ 508 750
Address
Via Francesco Sforza 28
20122 Milano
Activity type
Other
ALS AUTOMATED LAB SOLUTIONS GMBH
Germany
EU contribution
€ 781 343,75
Address
Otto-eppenstein-strasse 30
07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
POLITECHNIKA WARSZAWSKA
Poland
EU contribution
€ 496 875
Address
Plac Politechniki 1
00 661 Warszawa
Activity type
Higher or Secondary Education Establishments