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From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine GOal

Objective

FLAMIN-GO aims at developing an Organ-on-Chip technology for clinical trials on Rheumatoid Arthritis (RA). In RA, a number of unmet needs still persist particularly related to response/non-response of powerful but expensive drugs. Conventional clinical trials may address part of these challenges, but are time consuming, expensive and ethically ethically doubtful as part of the patients still fail to achieve disease benefits. Thus, the rheumatology community has a need for an alternative strategy that can deliver innovative trials.
FLAMIN-GO develops a personalized next-generation synovia-on-chip, that, by effectively mimicking the complexity of RA joint, will allow performing personalized clinical trials-on-chip. The solution will be based on design and fabrication of a multi-compartment microfluidic platform, for 3D culturing and perfusion of all the disease-relevant joint tissues. It focuses on synovia and synovial fluid, which are the pathogenetic targeted tissues, but including immune system, who sustain the disease, and cartilage and bone which are the end damaged tissues, leading to permanent disability. Starting from individual patient biopsies, this model seeks to replicate RA joints, thus allowing to test and allocate the best on-market drug for that patient in 1-2 months starting form biopsy. When validated, the platform will also be a turning point for i) pharma by enabling screening of new drugs reducing costs, time, and animal testing and for ii) translational research for identification of new biomarkers or therapeutic targets.
FLAMIN-GO consortium features a strong, well-balanced composition of hospital, academia and industry partners, who cover with complementary expertise the whole value chain. It gathers experts in the fields of rheumatology, material science, tissue engineering, nanotechnology, cell biology and 3D modelling, in a cohesive, transdisciplinary, multi-sectorial approach taking on the challenge to drive RA personalized care.

Field of science

  • /engineering and technology/other engineering and technologies/microtechnology/organ on a chip
  • /medical and health sciences/clinical medicine/rheumatology
  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/basic medicine/immunology
  • /medical and health sciences/medical biotechnology/tissue engineering

Call for proposal

H2020-NMBP-TR-IND-2020-twostage
See other projects for this call

Funding Scheme

RIA-LS - Research and Innovation action Lump Sum

Coordinator

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Address
Duomo 6
13100 Vercelli
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 908 703,79

Participants (13)

INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA
Portugal
EU contribution
€ 556 360,03
Address
Rua Alfredo Allen 208
4200 135 Porto
Activity type
Research Organisations
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 800 000
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 599 999,22
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
ASSOCIAZIONE PER LA RICERCA CHE CURA ORGANIZZAZIONE NON LUCRATIVA DI UTILITA SOCIALE
Italy
EU contribution
€ 50 625
Address
Corso Torino 29
28100 Novara
Activity type
Other
RIGAS TEHNISKA UNIVERSITATE
Latvia
EU contribution
€ 300 925,01
Address
Kalku Iela 1
1658 Riga
Activity type
Higher or Secondary Education Establishments
ENGINSOFT TURKEY MUHENDISLIK YAZILIM TICARET LIMITED SIRKETI
Turkey
EU contribution
€ 189 125
Address
Sanayi Mah Teknopark Bulvary No: 1/2A/102 Pendik
34906 Istanbul
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FLUIDIGM FRANCE SARL
France
EU contribution
€ 755 125
Address
1 Avenue De L'atlantique Les Conquerants Batiment Kilimandjaro
91940 Les Ulis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AO-FORSCHUNGSINSTITUT DAVOS
Switzerland
EU contribution
€ 498 097,51
Address
Clavadelerstrasse 8
7270 Davos Platz
Activity type
Research Organisations
TRUSTECH SRL
Italy
EU contribution
€ 439 375
Address
Piazza Solferino 20
10121 Torino
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 256 220,15
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
ZNANOST NA CESTI, ZAVOD ZA PROMOCIJO ZNANOSTI, LJUBLJANA
Slovenia
EU contribution
€ 60 250
Address
Teslova Ulica 30
1000 Ljubljana
Activity type
Other
REGENHU SA
Switzerland
EU contribution
€ 306 468,75
Address
Le Vivier 22
1690 Villaz-st-pierre
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU CORE CONSULTING SRL
Italy
EU contribution
€ 100 339,29
Address
Via Xx Settembre 98/E
00187 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)