From pathobioLogy to synoviA on chip: driving rheuMatoId arthritis to the precisioN medicine GOal

Objective

FLAMIN-GO aims at developing an Organ-on-Chip technology for clinical trials on Rheumatoid Arthritis (RA). In RA, a number of unmet needs still persist particularly related to response/non-response of powerful but expensive drugs. Conventional clinical trials may address part of these challenges, but are time consuming, expensive and ethically ethically doubtful as part of the patients still fail to achieve disease benefits. Thus, the rheumatology community has a need for an alternative strategy that can deliver innovative trials.
FLAMIN-GO develops a personalized next-generation synovia-on-chip, that, by effectively mimicking the complexity of RA joint, will allow performing personalized clinical trials-on-chip. The solution will be based on design and fabrication of a multi-compartment microfluidic platform, for 3D culturing and perfusion of all the disease-relevant joint tissues. It focuses on synovia and synovial fluid, which are the pathogenetic targeted tissues, but including immune system, who sustain the disease, and cartilage and bone which are the end damaged tissues, leading to permanent disability. Starting from individual patient biopsies, this model seeks to replicate RA joints, thus allowing to test and allocate the best on-market drug for that patient in 1-2 months starting form biopsy. When validated, the platform will also be a turning point for i) pharma by enabling screening of new drugs reducing costs, time, and animal testing and for ii) translational research for identification of new biomarkers or therapeutic targets.
FLAMIN-GO consortium features a strong, well-balanced composition of hospital, academia and industry partners, who cover with complementary expertise the whole value chain. It gathers experts in the fields of rheumatology, material science, tissue engineering, nanotechnology, cell biology and 3D modelling, in a cohesive, transdisciplinary, multi-sectorial approach taking on the challenge to drive RA personalized care.

Field of science

• /engineering and technology/other engineering and technologies/microtechnology/organ on a chip
• /medical and health sciences/clinical medicine/rheumatology
• /natural sciences/biological sciences/cell biology
• /medical and health sciences/basic medicine/immunology
• /medical and health sciences/medical biotechnology/tissue engineering

Programme(s)

• H2020-EU.2.1.3. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials
• H2020-EU.2.1.2. - INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies

Topic(s)

• DT-NMBP-23-2020 - Next generation organ-on-chip (RIA-LS)

Call for proposal

H2020-NMBP-TR-IND-2020-twostage
See other projects for this call

Funding Scheme

RIA-LS - Research and Innovation action Lump Sum

Coordinator

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO

Address

Duomo 6
13100 Vercelli
Italy

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 908 703,79

Participants (13)

INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA

Portugal

EU contribution

€ 556 360,03

Address

Rua Alfredo Allen 208
4200 135 Porto

Activity type

Research Organisations

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU contribution

€ 800 000

Address

Piazzale Aldo Moro 7
00185 Roma

Activity type

Research Organisations

QUEEN MARY UNIVERSITY OF LONDON

United Kingdom

EU contribution

€ 599 999,22

Address

327 Mile End Road
E1 4NS London

Activity type

Higher or Secondary Education Establishments

ASSOCIAZIONE PER LA RICERCA CHE CURA ORGANIZZAZIONE NON LUCRATIVA DI UTILITA SOCIALE

Italy

EU contribution

€ 50 625

Address

Corso Torino 29
28100 Novara

Activity type

Other

RIGAS TEHNISKA UNIVERSITATE

Latvia

EU contribution

€ 300 925,01

Address

Kalku Iela 1
1658 Riga

Activity type

Higher or Secondary Education Establishments

ENGINSOFT TURKEY MUHENDISLIK YAZILIM TICARET LIMITED SIRKETI

Turkey

EU contribution

€ 189 125

Address

Sanayi Mah Teknopark Bulvary No: 1/2A/102 Pendik
34906 Istanbul

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

FLUIDIGM FRANCE SARL

France

EU contribution

€ 755 125

Address

1 Avenue De L'atlantique Les Conquerants Batiment Kilimandjaro
91940 Les Ulis

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

AO-FORSCHUNGSINSTITUT DAVOS

Switzerland

EU contribution

€ 498 097,51

Address

Clavadelerstrasse 8
7270 Davos Platz

Activity type

Research Organisations

TRUSTECH SRL

Italy

EU contribution

€ 439 375

Address

Piazza Solferino 20
10121 Torino

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU contribution

€ 256 220,15

Address

Hofgartenstrasse 8
80539 Muenchen

Activity type

Research Organisations

ZNANOST NA CESTI, ZAVOD ZA PROMOCIJO ZNANOSTI, LJUBLJANA

Slovenia

EU contribution

€ 60 250

Address

Teslova Ulica 30
1000 Ljubljana

Activity type

Other

REGENHU SA

Switzerland

EU contribution

€ 306 468,75

Address

Le Vivier 22
1690 Villaz-st-pierre

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU CORE CONSULTING SRL

Italy

EU contribution

€ 100 339,29

Address

Via Xx Settembre 98/E
00187 Roma

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)