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Accelerating Research & Development for Advanced Therapies

Project description

Improving AAV gene therapy vector efficiency

Adeno-associated virus (AAV) is a non-enveloped virus that can be engineered to deliver DNA of interest to target cells for gene therapy purposes. However, pre-existing immunity renders AAV vectors inefficient as they get eliminated from the host. The EU-funded ARDAT project is bringing together experts in the field of gene therapy to fill the knowledge gaps regarding the immunogenicity of AAV vectors in gene therapy applications. Moreover, partners will study the metabolism of AAV gene therapy vectors, their degradation rate and their capacity to persist in episomal form. The long-term vision of ARDAT is to improve AAV vector efficiency in gene therapy trials.

Call for proposal

H2020-JTI-IMI2-2019-18-two-stage
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Coordinator

THE UNIVERSITY OF SHEFFIELD
Address
Firth Court Western Bank
S10 2TN Sheffield
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 699 812,25

Participants (33)

ASPHALION SL
Spain
EU contribution
€ 352 500
Address
Calle Tarragona, Numeros 151-157, Planta 10, Bloqu
08014 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 245 026,25
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Portugal
EU contribution
€ 630 000
Address
Universidade De Coimbra Largo Marques De Pombal
3004 517 Coimbra
Activity type
Research Organisations
ASSOCIATION GENETHON
France
EU contribution
€ 311 250
Address
Rue De L Internationale 1 Bis
91002 Evry
Activity type
Research Organisations
GENOSAFE SAS
France
EU contribution
€ 299 657,50
Address
Rue De L'internationale 1
91000 Evry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA
Portugal
EU contribution
€ 400 000
Address
Avenida Da Republica Quinta Do Marques
2781-901 Oeiras
Activity type
Research Organisations
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
France
EU contribution
€ 250 000
Address
Boulevard De L'hopital 47
75013 Paris
Activity type
Research Organisations
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 298 517,50
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
LUNDS UNIVERSITET
Sweden
EU contribution
€ 175 625
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
LYSOGENE
France
EU contribution
€ 450 000
Address
18-20 Rue Jacques Dulud
92200 Neuilly Sur Seine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 177 718,75
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
MIMETAS BV
Netherlands
EU contribution
€ 318 420
Address
Jh Oortweg 19
2333CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT
Hungary
EU contribution
€ 502 090
Address
Derkovits Fasor 7-11
6726 Szeged
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SYNVACCINE LTD
Israel
EU contribution
€ 229 000
Address
Habarzel St 27
6971039 Tel Aviv
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TAKIS SRL
Italy
EU contribution
€ 225 062,50
Address
Via Di Castel Romano 100
00128 Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 324 740
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
THE ROSALIND FRANKLIN INSTITUTE
United Kingdom
EU contribution
€ 412 930
Address
Research Complex At Harwell Rutherford Appleton La Harwell Science And Innovation Campus
OX11 0FA Didcot
Activity type
Research Organisations
THE UNIVERSITY OF LIVERPOOL
United Kingdom
EU contribution
€ 1 000 000
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM HEIDELBERG
Germany
EU contribution
€ 300 000
Address
Im Neuenheimer Feld 672
69120 Heidelberg
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 972 521,25
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 571 250
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 626 878,75
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
PFIZER LIMITED
United Kingdom
EU contribution
€ 0
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BAYER AKTIENGESELLSCHAFT
Germany
EU contribution
€ 0
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
€ 0
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LONZA AG
Switzerland
EU contribution
€ 0
Address
Muenchensteinerstrasse 38
4002 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 0
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NOVO NORDISK A/S
Denmark
EU contribution
€ 0
Address
Novo Alle 1
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
EU contribution
€ 0
Address
Pierre Brossolette 1
91380 Chilly Mazarin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SPARK THERAPEUTICS, INC
United States
EU contribution
€ 0
Address
251 Little Falls Drive
19808 Wilmington
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TAKEDA PHARMACEUTICALS INTERNATIONAL AG
Switzerland
EU contribution
€ 0
Address
Thurgauerstrasse 130
8152 Glattpark
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
VISCOFAN SA
Spain
EU contribution
€ 0
Address
Calle Berroas 15 4 Planta
31192 Aranguren
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASTELLAS PHARMA EUROPE BV
Netherlands
EU contribution
€ 0
Address
Sylviusweg 84
2333 BE Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)