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Elucidating the mechanisms, heterogeneity and role of epigenetic topological alterations in cancer

Project description

Uncovering the role of epigenetic changes in chromosomal structure in cancer

Cancer genomics allowed systematic mapping of oncogenic genetic alterations of genes. However, oncogenic epigenetic alterations of regulatory elements away from genes remain unknown. Recently, it was demonstrated that aberrant DNA methylation of CTCF binding sites perturbs chromosomal topology in IDH-mutant glioma and SDH-deficient gastrointestinal stromal tumours. Losing CTCF binding at the border between two topologically associating domains disrupts their insulation, leading to oncogene activation. This pioneering model connects metabolic, epigenetic and topological alterations demonstrating potential oncogenesis. The EU-funded CancerEpiTopology project will develop new statistical models and experimental approaches to systematically map and understand the regulation of DNA methylation at CTCF binding sites. It will show how its disruption in cancer leads to epigenetic heterogeneity and drives oncogenesis.

Host institution

THE HEBREW UNIVERSITY OF JERUSALEM
Net EU contribution
€ 1 500 000,00
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Israel

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 500 000,00

Beneficiaries (1)

THE HEBREW UNIVERSITY OF JERUSALEM
Israel
Net EU contribution
€ 1 500 000,00
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem

See on map

Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 500 000,00