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Metaplasia as an adaptive response to chronic microbial infections

Project description

A closer look at mechanisms of epithelial tissue cancers

Chronic gastric infection related to helicobacter pylori is an example of how chronic bacterial infection can induce human cancers of epithelial tissue. Despite its frequent occurrence, the exact mechanisms of microbe-induced epithelial cancer remain unexplained. However, recent research suggests that the precancerous phase of gastric intestinal metaplasia (GIM) could be a form of an organism’s antimicrobial adaptive defence. The EU-funded MADMICS project will investigate this hypothesis to bring new light to the role of bacterial infections in human cancer development. The project will also look at mutational and epigenetic changes connected to GIM as well as a new means of cancer prevention.

Call for proposal

ERC-2019-ADG
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Host institution

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Address
Olshausenstrasse 40
24118 Kiel
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 500 000

Beneficiaries (1)

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 2 500 000
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments