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Towards optogenetic cortical implants for hearing impaired

Objective

Cochlear implants are the first and currently most successful sensory rehabilitation strategy, and equip thousands of hearing impaired patients. However, they suffer from strong information throughput limitations, making music perception and speech intelligibility in noise impossible, extremely detrimental to implanted patients. In this project, we propose to establish a clear proof of concept for a radically new auditory rehabilitation strategy by direct stimulation of the main sound processing center in the brain, the auditory cortex. The auditory cortex not only offers one order of magnitude more interfacing surface, to boost information throughput, but it is also a plastic structure, adaptable to complex auditory codes, which could benefit from acoustic information preprocessing by modern artificial intelligence algorithms. To demonstrate that cortical implants are feasible and outperform cochlear implants, artificial sound perceptions will be optogenetically generated via an LED display placed over the full extent of auditory cortex in behaving mice. Perceptual precision for a wide range of acoustic features will be precisely benchmarked against cochlear implant thanks to a range of psychophysical assays available in this animal model. The benefits of sound preprocessing by machine learning algorithm s(deep learning networks) will be tested, and we will develop a new generation of ultrathin, flexible, biocompatible LED displays, that could be placed on the convoluted surface of human auditory cortex to activate precise and rich perceptions. Together, these brain-interfacing and bioelectronics innovations will enable a new implant strategy in that promises to be a major changer for hearing restoration quality in deaf patients, and pave the way for improvement of other sensory restoration strategies.

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT PASTEUR
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
France
Activity type
Research Organisations
EU contribution
€ 698 232,50

Participants (5)

UNIVERSITAT BASEL
Switzerland
EU contribution
€ 521 048,75
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU
Norway
EU contribution
€ 550 916,25
Address
Hogskoleringen 1
7491 Trondheim
Activity type
Higher or Secondary Education Establishments
INSTITUT MINES-TELECOM
France
EU contribution
€ 437 263,75
Address
19 Place Marguerite Perey
91120 Palaiseau
Activity type
Higher or Secondary Education Establishments
NOVAGAN SARL
Switzerland
EU contribution
€ 493 772,50
Address
Chemin De Mornex 5 A
1003 Lausanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY OF STRATHCLYDE
United Kingdom
EU contribution
€ 298 737,50
Address
Richmond Street 16
G1 1XQ Glasgow
Activity type
Higher or Secondary Education Establishments