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Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients

Objective

TIMESPAN's main objective is to advance the management of patients with Attention Deficit Hyperactivity Disorders (ADHD) and co-occurring cardiometabolic disease by improving available treatments and risk stratification. Emerging evidence points at substantial comorbidity and shared genetics between adult ADHD and cardiometabolic diseases (i.e., Obesity, Type-2 Diabetes and cardiovascular disease). Inadequate treatment of cardiometabolic disease is strongly associated with premature death and substantial societal costs. National guidelines of cardiometabolic disease have stressed the importance of co-occurring psychiatric disorders. However, even though ADHD is a common (prevalence ≈2 to 5% in adults) and serious complex chronic condition, knowledge about appropriate management of adults with ADHD and co-occurring cardiometabolic disease is lacking. We will address the main objective using existing large-scale cohort studies and linked electronic health record databases in multiple countries with different health care systems. We also use smartphones and wearable devices to obtain novel real-time and multi-parametric measurements of ADHD medication treatment and cardiometabolic risks. The combined use of unparalleled data sources and new technologies for data collection, management, analytics will identify optimized and personalized multidisciplinary treatment approaches that minimise harm and maximise positive changes in disease prognosis and improve treatment discontinuity. TIMESPAN is expected to improve the clinical outcomes, as well as quality of life in adult ADHD patients with co-occurring cardiometabolic disease and also to also facilitates developments of new technological tools for advanced data management, monitoring and analytics for European stakeholders. TIMESPAN strategies to inform clinicians, patients, health authorities, and general public allow for a sustainable implementation of our findings (e.g. recommendations for treatment guidelines).

Call for proposal

H2020-SC1-2020-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

OREBRO UNIVERSITY
Address
Fakultetsgatan 1
70182 Orebro
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 366 750

Participants (16)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 400 000
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
AARHUS UNIVERSITET
Denmark
EU contribution
€ 600 000
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 400 000
Address
Museplassen 1
5020 Bergen
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 400 000
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 499 986
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 1 520 000
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
TARTU ULIKOOL
Estonia
EU contribution
€ 200 000
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 200 000
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
United States
EU contribution
€ 400 000
Address
State Street 35
12201 Albany Ny
Activity type
Other
HASKOLI ISLANDS
Iceland
EU contribution
€ 100 000
Address
Saemundargotu 2
101 Reykjavik
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF NEW SOUTH WALES
Australia
EU contribution
€ 0
Address
Anzac Parade
2052 Sydney
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF HONG KONG
Hong Kong
EU contribution
€ 0
Address
Pokfulam Road
Pokfulam
Activity type
Higher or Secondary Education Establishments
ADD INFORMATION SERVICES
United Kingdom
EU contribution
€ 30 000
Address
10Th Floor, Hyde House, Colindale
NW9 6LH London
Activity type
Other
THE EUROPEAN ASSOCIATION FOR THE STUDY OF OBESITY - IRELAND COMPANY LIMITED BY GUARANTEE
Ireland
EU contribution
€ 25 000
Address
Molesworth House 1-2 South Frederick Street
D02 N820 Dublin
Activity type
Other
EMPATICA SRL
Italy
EU contribution
€ 300 000
Address
Via Enrico Stendhal 36
20144 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Concentris Research Management GmbH
Germany
EU contribution
€ 558 250
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)