Skip to main content

POLYRISK - Understanding human exposure and health hazard of micro- and nanoplastic contaminants in our environment

Objective

The POLYRISK project aims unraveling the risks of microplastic and nanoplastic particles (MNP) that are ubiquitous in our environment and are likely to be entering the human body via inhalation and ingestion. The most bioavailable low-micron and nano-sized MNP, pose the biggest analytical challenges or today’s analytical chemists. Existing knowledge about the adverse pro-inflammatory effects of airborne particulate matter and nanoparticles, combined with pro-inflammatory evidence of MNP exposure observed in animal models and in vitro pilot tests with human immune cells, suggests that MNP may cause immunotoxicity in humans. Occupational exposure of workers to fibrous MNP can indeed lead to granulomatous lesions, causing respiratory irritation, functional abnormalities and flock worker’s lung. Currently, human health risk assessment protocols specific to MNP are not available and key data is missing. This hampers science-based decision making.
On this backdrop, POLYRISK’s human risk assessment strategy will combine highly advanced sampling, sample pretreatment and analytical methods to detect MNP in complex matrices, up-to-date fit-for-purpose hazard assessment technologies and multiple real-life human exposure scenarios. We will focus on key toxic events linked to several chronic inflammatory diseases.
The consortium uniquely brings together interdisciplinary experience and know-how on quality-controlled chemical analyses of MNP and additives, intestinal and respiratory toxicity models, human exposure epidemiology, immunotoxicology and real-life high-exposure studies. POLYRISK’s novel human risk assessment strategy is based on mechanistic reasoning and pragmatically accommodates the complexity of the MNP toxicant class. Building with ground-breaking science, stakeholder engagement and strong communication, POLYRISK aims to rapidly reduce current MNP risk uncertainties and support EU efforts to ensure public health is adequately protected from the potential risks of MNP pollution. POLYRISK is a part of the European cluster on Health Impacts of Micro- and Nanoplastics.

Call for proposal

H2020-SC1-2020-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITEIT UTRECHT
Address
Heidelberglaan 8
3584 CS Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 316 412,50

Participants (14)

STICHTING VU
Netherlands
EU contribution
€ 788 443,75
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
STICHTING VUMC
Netherlands
EU contribution
€ 362 500
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
BUNDESINSTITUT FUER RISIKOBEWERTUNG
Germany
EU contribution
€ 612 000
Address
Max Dohrn Strasse 8-10
10589 Berlin
Activity type
Research Organisations
BUNDESANSTALT FUER MATERIALFORSCHUNG UND -PRUEFUNG
Germany
EU contribution
€ 262 500
Address
Unter Den Eichen 87
12205 Berlin
Activity type
Research Organisations
BUNDESANSTALT FUER ARBEITSSCHUTZ UND ARBEITSMEDIZIN
Germany
EU contribution
€ 108 125
Address
Friedrich Henkel Weg 1-25
44149 Dortmund
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
FOLKEHELSEINSTITUTTET
Norway
EU contribution
€ 862 133,75
Address
Lovisenberggata 8
0456 Oslo
Activity type
Research Organisations
INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE
Romania
EU contribution
€ 120 047,50
Address
Lucretiu Patrascanu 16
030508 Bucuresti
Activity type
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 192 375
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Italy
EU contribution
€ 185 250
Address
Lungotevere Grande Ammiraglio Thaon Di Revel 76
000196 Roma
Activity type
Research Organisations
IDEACONSULT LIMITED LIABILITY COMPANY
Bulgaria
EU contribution
€ 188 500
Address
Angel Kanchev 4
1000 Sofia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HEALTH AND ANVIRONMENT ALLIANCE HEAL AISBL
Belgium
EU contribution
€ 219 875
Address
Boulevard Charlemagne 28
1000 Bruxelles
Activity type
Other
FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Germany
EU contribution
€ 420 415
Address
Hansastrasse 27C
80686 Munchen
Activity type
Research Organisations
EUROPEAN RESEARCH SERVICES GMBH
Germany
EU contribution
€ 227 500
Address
Roentgenstrasse 19
48149 Muenster
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UMWELTBUNDESAMT
Germany
EU contribution
€ 125 000
Address
Woerlitzer Platz 1
06844 Dessau-rosslau
Activity type
Research Organisations