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Switchable rhodOpsins in Life Sciences

Project description

Understanding structure–function relationships of bistable rhodopsins

Bistable rhodopsins are naturally photosensitive G-protein coupled receptors (GPCRs) responsible for photosensitivity and vision in animals. Bistable rhodopsins are also a potential source of strong optogenetic tools allowing bidirectional control of influential intracellular signalling cascades in all light-using body systems. However, knowledge of their biology and their engineering for optogenetic scopes is restricted due to limited understanding of their structure–function relationships. The EU-funded SOL project will investigate how structural characteristics of these influential photoreceptors determine their bistability, bichromicity, kinetics and G-protein selectivity. The project will apply this knowledge for rational engineering towards colour tuning and G-protein selectivity for optogenetic tools and investigate physiological functions. SOL will produce pioneering optogenetic techniques allowing for definition of GPCR signalling activities.

Call for proposal

ERC-2020-SyG
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Host institution

PAUL SCHERRER INSTITUT
Address
Forschungstrasse 111
5232 Villigen Psi
Switzerland
Activity type
Research Organisations
EU contribution
€ 2 552 015

Beneficiaries (4)

PAUL SCHERRER INSTITUT
Switzerland
EU contribution
€ 2 552 015
Address
Forschungstrasse 111
5232 Villigen Psi
Activity type
Research Organisations
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
EU contribution
€ 2 437 500
Address
Unter Den Linden 6
10117 Berlin
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET BERN
Switzerland
EU contribution
€ 2 499 125
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 2 500 000
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments