Skip to main content

Switchable rhodOpsins in Life Sciences

Project description

Understanding structure–function relationships of bistable rhodopsins

Bistable rhodopsins are naturally photosensitive G-protein coupled receptors (GPCRs) responsible for photosensitivity and vision in animals. Bistable rhodopsins are also a potential source of strong optogenetic tools allowing bidirectional control of influential intracellular signalling cascades in all light-using body systems. However, knowledge of their biology and their engineering for optogenetic scopes is restricted due to limited understanding of their structure–function relationships. The EU-funded SOL project will investigate how structural characteristics of these influential photoreceptors determine their bistability, bichromicity, kinetics and G-protein selectivity. The project will apply this knowledge for rational engineering towards colour tuning and G-protein selectivity for optogenetic tools and investigate physiological functions. SOL will produce pioneering optogenetic techniques allowing for definition of GPCR signalling activities.

Host institution

PAUL SCHERRER INSTITUT
Net EU contribution
€ 2 552 015,00
Address
Forschungstrasse 111
5232 Villigen Psi
Switzerland

See on map

Region
Schweiz/Suisse/Svizzera Nordwestschweiz Aargau
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Beneficiaries (5)

PAUL SCHERRER INSTITUT
Switzerland
Net EU contribution
€ 2 552 015,00
Address
Forschungstrasse 111
5232 Villigen Psi

See on map

Region
Schweiz/Suisse/Svizzera Nordwestschweiz Aargau
Activity type
Research Organisations
Non-EU contribution
€ 0,00
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
Net EU contribution
€ 2 346 875,00
Address
Unter Den Linden 6
10117 Berlin

See on map

Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAET BERN

Participation ended

Switzerland
Net EU contribution
€ 0,00
Address
Hochschulstrasse 6
3012 Bern

See on map

Region
Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE UNIVERSITY OF MANCHESTER
United Kingdom
Net EU contribution
€ 2 859 998,75
Address
Oxford Road
M13 9PL Manchester

See on map

Region
North West (England) Greater Manchester Manchester
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAETSKLINIKUM FREIBURG
Germany
Net EU contribution
€ 212 500,00
Address
Hugstetter Strasse 49
79106 Freiburg

See on map

Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00