Project description
Complex organ-on-a-chip system for biomedical research
Organoid technology has achieved a breakthrough in biomedicine, with high potential for viral pathogenesis and antiviral research. The EU-funded GUTVIBRATIONS project will combine expertise in microfabrication, organoid technology, virology, immunology, and bioengineering to create an organ-on-a-chip system as a modular human gut-brain axis multi-organ model. This system will be built by combining 3D-printed scaffold technology with human gut and brain organoids. It will include a gut epithelial layer, immune cells, a blood-brain barrier and a brain organoid, connected by vertical stacking. The extracellular matrix (ECM) scaffold called Biosilk, a recombinant spider silk protein, will result in an in vivo like microenvironmental niche. The project aims to assess the system's commercialisation by a market analysis and a business plan.
Fields of science
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencesinfectious diseases
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinephysiology
- engineering and technologyother engineering and technologiesmicrotechnologyorgan on a chip
Programme(s)
Funding Scheme
RIA-LS - Research and Innovation action Lump SumCoordinator
1105AZ Amsterdam
Netherlands
See on map
Participants (6)
2800 Kgs Lyngby
See on map
3000 Leuven
See on map
1105BP Amsterdam
See on map
172 66 Sundbyberg
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
CB25 9TL Cambridge
See on map
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
100 44 Stockholm
See on map