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Establishing innovative approaches for optimal infection prevention of resistant bacteria in NICUs by integrating research, implementation science and surveillance in a sustainable global platform

Objective

Around 10% of newborns in Europe will be admitted to a neonatal intensive care unit (NICU). Critically ill babies are a highly vulnerable population for the acquisition of resistant bacteria. Sepsis is among the most common events in NICU and is known to be associated with high mortality and poor long-term outcomes. Despite rising awareness of high rates of resistant bacterial colonisation reported in NICU, there is very little robust specific data on globally applicable infection prevention and control (IPC) measures. NeoIPC focuses on new approaches to the prevention and management of resistant bacterial colonization and infection on NICU. The project builds on and further extends the collaboration between 13 partners with a proven track record in relevant areas, including neonatal infection, IPC, implementation science, microbiology and surveillance. NeoIPC aims to develop and implement an innovative approach towards the evaluation of IPC interventions combining a robust cost-efficient randomised trial combined with the evaluation of a suitable implementation science strategy and novel targeted clinical and genotypic surveillance. A further goal is to generate widely relevant pan-European network strategies to improve IPC in routine neonatal care. This will be achieved through six interrelated work packages to deliver a cluster randomised trial-implementation hybrid investigating the impact of skin antisepsis on infant hospital-acquired clinical sepsis and resistant bacterial colonisation, coupled with a comprehensive implementation strategy incorporating optimal targeted surveillance in a clinical network with tailored dissemination and exploitation to facilitate sustainable embedding of outputs. NeoIPC will generate globally transferrable outputs to reduce hospital transmission of resistant pathogens, foster and facilitate collaborative research and IPC implementation efforts with a broad and long-lasting impact for critically ill newborns and infants.

Call for proposal

H2020-SC1-2020-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA
Address
Via 8 Febbraio 2
35122 Padova
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 283 091,25

Participants (11)

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 941 546,25
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 1 484 496,25
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 633 216,25
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
TARTU ULIKOOL
Estonia
EU contribution
€ 228 965
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT
Switzerland
EU contribution
€ 446 126,25
Address
Socinstrasse 57
CH-4002 Basel
Activity type
Research Organisations
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
EU contribution
€ 186 076,25
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 1 495 981,25
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 740 237,50
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Servicio Vasco de Salud Osakidetza
Spain
EU contribution
€ 205 001,25
Address
Alava 45
01006 Vitoria-gasteiz
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
STELLENBOSCH UNIVERSITY
South Africa
EU contribution
€ 169 391,25
Address
Victoria Street Administration B Building
7600 Stellenbosch
Activity type
Higher or Secondary Education Establishments
FONDAZIONE PENTA - FOR THE TREATMENT AND CARE OF CHILDREN WITH HIV ANDRELATED DISEASES - ONLUS
Italy
EU contribution
€ 3 185 688
Address
Corso Stati Uniti 4
35127 Padova
Activity type
Research Organisations