Antiviral immune responses: a battle of the sexes
Men who test positive for COVID-19 are more likely to require intensive care than women are. They are also more likely to die. The evidence points to sex differences in immune responses to viral infection. In search of answers, the EU-funded SHIFT project will study sex-specific regulation of immune responses. By studying the immune system of individuals as they undergo sex reassignment therapy with sex hormones, the project will explore the contribution of sex hormones to human antiviral immune function. The identification of sex hormone regulated pathways in antiviral immunity will be valuable for vaccine design, antiviral therapies and immunomodulatory therapies.
Fields of science
- social sciencessociologydemographymortality
- medical and health sciencesbasic medicineimmunology
- medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals