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Dissecting the role of sex hormones in human antiviral immunity

Project description

Antiviral immune responses: a battle of the sexes

Men who test positive for COVID-19 are more likely to require intensive care than women are. They are also more likely to die. The evidence points to sex differences in immune responses to viral infection. In search of answers, the EU-funded SHIFT project will study sex-specific regulation of immune responses. By studying the immune system of individuals as they undergo sex reassignment therapy with sex hormones, the project will explore the contribution of sex hormones to human antiviral immune function. The identification of sex hormone regulated pathways in antiviral immunity will be valuable for vaccine design, antiviral therapies and immunomodulatory therapies.

Coordinator

KAROLINSKA INSTITUTET
Net EU contribution
€ 191 852,16
Address
Nobels Vag 5
17177 Stockholm
Sweden

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00