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Deciphering the mechanisms of developmentally regulated centriole elimination

Project description

Shedding light into centriole elimination during oogenesis

Centrioles are cellular organelles that support the formation of the locomotion structures cilia and flagella as well as centrosomes. During sexual reproduction, only the sperm contributes centrioles to the zygote, whereas centrioles are eliminated from the oocyte. Still, the underlying mechanism remains unknown. The EU-funded CENTEL project will employ Caenorhabditis elegans to unveil the mechanism by which centrioles are eliminated during oogenesis. Researchers will apply live imaging and conduct a proteomic screen to identify the key players in the process. Among the key objectives is to disclose the extent by which centriole elimination has been evolutionary conserved.

Call for proposal

H2020-MSCA-IF-2020
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Coordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Switzerland

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Activity type
Higher or Secondary Education Establishments
EU contribution
€ 191 149,44