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ElectroMechanoActive Polymer-based Scaffolds for Heart-on-Chip

Objective

Cardiovascular diseases (CVDs) account for 45% of deaths in Europe and are estimated to cost the EU economy €210 billion a year. However, only four drugs targeting cardiovascular diseases have been approved for use in the last decade. Thus, models that could effectively simulate diseased tissues, would enable the accurate assessment of the efficacy of the pharmaceuticals, and would accelerate drug development are urgently needed. The main bottleneck towards such models is the foetal-like state of the human induced pluripotent stem cell (hiPSC) derived cardiomyocytes (CMs). That is hiPSC-CMs do not reach adult-like maturity. The objective of this project is to produce a platform for growth and maturation of cardiac microtissues for adult-like organotypic models in healthy and diseased states. To achieve that, biomimetic microenvironment that provides all the needed stimuli (electrical, mechanical, topological (3D environment) and biochemical (release of active molecules)), during the maturation of hiPSC-CMs will be developed. This will be achieved by combining electro-mechanoactive polymer-based scaffolds (EMAPS) with bioactive membranes. To characterize the effects of CVD drugs, the contractility of the microtissue will be monitored continuously and simultaneously (over 24-wells) using the sensors developed during the project. To increase the sensitivity and accuracy of the model, deep-learning based algorithms to detect the effects of drugs in vitro will be developed and verified. The goals will be achieved by a multidisciplinary consortium with complementary know-how of three academic units and seven small companies. The increased sensitivity and accuracy of organ-on-chip devices is a needed leap in technology that will accelerate new drug development without the need for animal models; the project aims to provide a platform for the realization of such physiologically-relevant organotypic models.

Call for proposal

H2020-NMBP-TR-IND-2020-twostage
See other projects for this call

Funding Scheme

RIA-LS - Research and Innovation action Lump Sum

Coordinator

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Address
Rue Michel Ange 3
75794 Paris
France
Activity type
Other
EU contribution
€ 698 136,76

Participants (8)

BIOTALENTUM TUDASFEJLESZTO KFT
Hungary
EU contribution
€ 1 021 875
Address
Aulich Lajos Utca 26
2100 Goedoello
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INOCURE SRO
Czechia
EU contribution
€ 646 250
Address
Politickych Veznu 935/13
11000 Praha
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
VALSTYBINIS MOKSLINIU TYRIMU INSTITUTAS INOVATYVIOS MEDICINOS CENTRAS
Lithuania
EU contribution
€ 736 250
Address
Santariskiu G 5
08406 Vilnius
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
OSPIN GMBH
Germany
EU contribution
€ 456 625
Address
Feurigstrasse 54
10827 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT
Switzerland
EU contribution
€ 560 115,50
Address
Rue Jaquet Droz 1
2000 Neuchatel
Activity type
Research Organisations
BIOFABICS LDA
Portugal
EU contribution
€ 404 418,99
Address
Rua Alfredo Allen 455/461
4200-135 Porto
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 427 250
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACIO EURECAT
Spain
EU contribution
€ 405 000
Address
Avenida Universitat Autonoma 23
08290 Cerdanyola Del Valles (Barcelona)
Activity type
Research Organisations