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Role of DNA methylation reprogramming in germline stress response

Project description

DNA methylation reprogramming in plants

DNA methylation (DM) is essential for organism development and is involved in a variety of biological processes, including transcriptional regulation, transposon silencing, chromosome inactivation and genomic imprinting. This stable epigenetic mark, however, needs to be reprogrammed to a totipotent state for producing the next generation. Epigenetic reprogramming involves the erasure of methylation marks inherited from the gametes at preimplantation stages and the reestablishment of global DM patterns upon implantation. DM reprogramming was found in male germlines of flowering plants. Funded by the Marie Skłodowska-Curie Actions programme, the MASTER project aims to elucidate the scope, mechanism and environmental adaptation function of female and male germline DM reprogramming in Arabidopsis using a combination of single-cell genomics, epigenetics and developmental biology approaches.

Coordinator

JOHN INNES CENTRE
Net EU contribution
€ 224 933,76
Address
Norwich Research Park Colney
NR4 7UH Norwich
United Kingdom

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Region
East of England East Anglia Breckland and South Norfolk
Activity type
Research Organisations
Non-EU contribution
€ 0,00