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Continuous two-dimensional Stretch monitoring of fresh tissue Biopsies

Objective

Mechanical tension and stresses are considered key factors associated to the control of the growth and proliferation of tumoral cells and tissues. Monitoring of such stresses would help to better understand cancer progression and also to test the effectiveness of anticancer drugs aiming to restore normal tissue mechanics. However, there is no current system available for monitoring the cellular mechanical properties, particularly for small tissue biopsies like those obtained with core needles.
The overall goal of the StretchBio project is the design, development, fabrication and proof of application of an advanced label-free and compact nanosystem for the continuous monitoring and quantification of mechanical stresses in ex vivo fresh tissue biopsies. This nanodevice will allow testing the changes of these tissues upon their treatment with anticancer drugs for improved drug screening. The basic principle of StretchBio is a two-dimensional force sensor based on an array of nanopillars, constituting a photonic crystal, in which the bending of one or more nanopillars, caused by the mechanical forces exerted by the living tissue, will give rise to a change in the transmitted light through the photonic crystal. The design and fabrication of this compact nanosystem needs to be addressed in concomitance with liquid cell culture media, which will constitute the interpillar medium, and with the fact that the ex vivo fresh biopsy needs to be placed on top of the nanopillars.
The proposed approach will be an enormous leap in the study of tissue growth and of drug screening in solid tumours whose progression is markedly contributed by tissue stiffening. This represents an innovative approach to personalized medicine, allowing the development of ad-hoc treatments.

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Coordinator

UNIVERSITAT DE BARCELONA
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 418 750

Participants (4)

DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 1 111 421,25
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 716 687,50
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Spain
EU contribution
€ 275 037,50
Address
Carrer De La Innovacio 2
08225 Terrassa
Activity type
Research Organisations
READYCELL SL
Spain
EU contribution
€ 300 798,75
Address
Calle Pallars 179-185
08005 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)