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Understanding and manipulating the dysregulation of interneurons in schizophrenia

Project description

Mechanistic insight into schizophrenia development

Schizophrenia is a serious mental illness associated with psychosis and distorted perception of reality. Although patients present with increased dopamine levels before psychosis and suspected abnormal activity of midbrain dopamine neurons, the precise mechanisms remain elusive. The EU-funded SchizoFree project aims to shed light on the aetiology of dopamine neuron dysregulation in schizophrenia. Using a mouse model of the disease, researchers will investigate the role of cortical and striatal interneurons in the development of schizophrenia. They hope to identify biomarkers for prompt disease diagnosis and design novel treatments that alleviate schizophrenia symptoms.

Coordinator

KING'S COLLEGE LONDON
Net EU contribution
€ 212 933,76
Address
Strand
WC2R 2LS London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00