Study of the cellular entry mechanisms for coronaviruses with different pathogenicity
Coronaviruses (CoVs) have created several outbreaks, including the current global pandemic. Some viruses of this family cause only mild conditions, and the reasons for variations in the severity of the diseases are poorly understood. CoVs attach to the cells via a specific interaction between the viral spike glycoprotein (CoV-S) and receptors on the cell surface. The EU-funded CoVentry project is investigating the early entry mechanism of CoV-SARS, CoV-SARS2 and hCoV-NL63, variants with different pathogenicity, which share the same cellular receptor angiotensin-converting enzyme 2. The project focuses on the characterisation of the viruses' interactions with the cell surface, including the bonds between individual CoV-S and single membrane components and multivalent interactions at the cell surface.
Fields of science
- natural sciencesbiological sciencesmicrobiologyvirology
- medical and health scienceshealth sciencespublic healthepidemiologypandemics
- medical and health scienceshealth sciencesinfectious diseasesRNA virusescoronaviruses
- natural sciencesbiological sciencesbiophysics
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes