Skip to main content

E3-hijacking molecular glues of RNA binding protein IGF2BP1 in ovarian cancer

Project description

A novel drug design approach against cancer targets

Most small-molecule drugs against proteins usually target a regulatory moiety or the enzymatic active centre. However, there are molecular targets where this strategy cannot be implemented. The EU-funded E3glueRBP project proposes to address this issue through small molecules that induce interaction between two proteins and cause degradation of the disease-associated target. The team will develop a platform that utilises computational and biochemical methods to predict such protein domains and design appropriate molecular inhibitors. Project results will advance the field of cancer drug development and expand current therapeutic opportunities.

Call for proposal

H2020-WF-2018-2020

See other projects for this call

Sub call

H2020-WF-03-2020

Coordinator

INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
Net EU contribution
€ 159 815,04
Address
Avenida Prof Egas Moniz
1649 028 Lisboa
Portugal

See on map

Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Research Organisations
Other funding
€ 0,00