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Helical foldamers with tunable channels for transmembrane water and ion transport

Project description

Improved synthetic structures to mimic biological ion and water channels

In higher organisms, cells are surrounded by membranes that separate them from the external environment and mediate the exchange of fluids, electrolytes or proteins. These membranes are typically composed of proteins that act like channels that open and close in response to selective ions and molecules. Research has largely focused on engineered biological ion channels to further understand their mechanism and how they could potentially treat certain diseases, such as channelopathies. Funded by the Marie Skłodowska-Curie Actions programme, the HeliTrans project plans to synthesise the first unimolecular synthetic ion or water channel. The project will build on earlier achievements in aromatic foldamer design to improve the selectivity of the synthetic ion and water channels.


Net EU contribution
€ 174 806,40
Geschwister Scholl Platz 1
80539 Muenchen

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Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00