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Study of the role of mitophagy and lysosomal biogenesis in COX deficiency: a new model for drug discovery

Project description

Exploiting cell endogenous degradation approaches to treat mitochondrial diseases

Mitochondria are key cellular organelles responsible for energy production. Mitochondria dysfunction can be detrimental to cell viability and lead to neuromuscular disorders known as mitochondrial myopathies. The EU-funded MTPHAGYTREAT project is working on a novel approach to treat mitochondria dysfunction by inducing mitochondria degradation through the natural mechanism of removing unwanted or damaged organelles known as autophagy. To investigate this approach, researchers will develop a mouse model that recapitulates the genetic defects of human disease. This model can also serve as a platform for testing various natural compounds for the treatment of mitochondrial diseases.

Coordinator

UNIVERSITA DEGLI STUDI DI PADOVA
Net EU contribution
€ 183 473,28
Address
Via 8 Febbraio 2
35122 Padova
Italy

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Region
Nord-Est Veneto Padova
Activity type
Higher or Secondary Education Establishments
Other funding
€ 183 473,28