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Directed co-evolution via engineered cell-to-cell communication

Project description

Novel directed evolution approach to advance control over cell signalling pathways

The EU-funded Evolving together project develops an innovative system for directed co-evolution of cellular ligand-receptor pairs. The cell-to-cell directed evolution platform will facilitate the development of synthetic, orthogonal intercellular signalling pathways to enable user-defined expression of target genes. High flexibility in selection of the reporter genes enables full customisation of the downstream cellular response, such as programming self-organised cellular patterns or targeting specific cell populations. The project presents an opportunity to create a directed evolution approach with an impact in various fields of biology and biomedicine.

Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Net EU contribution
€ 212 933,76
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00