Novel directed evolution approach to advance control over cell signalling pathways
The EU-funded Evolving together project develops an innovative system for directed co-evolution of cellular ligand-receptor pairs. The cell-to-cell directed evolution platform will facilitate the development of synthetic, orthogonal intercellular signalling pathways to enable user-defined expression of target genes. High flexibility in selection of the reporter genes enables full customisation of the downstream cellular response, such as programming self-organised cellular patterns or targeting specific cell populations. The project presents an opportunity to create a directed evolution approach with an impact in various fields of biology and biomedicine.