Project description
Molecular events in herpes simplex virus type 1 replication
Herpes simplex virus type 1 (HSV-1) is a widespread pathogen. However, the regulation of its genome replication is not well understood. The current model of HSV-1 genome replication includes an origin-dependent phase followed by an origin-independent phase. Funded by the Marie Skłodowska-Curie Actions programme, the HSV1_Single_Molecule project aims to elucidate molecular events of the less studied origin-independent replication phase using single-molecule imaging techniques. Previously, it was found that the HSV-1 origin binding protein UL9 is necessary for the origin-dependent but dispensable or inhibitory in the origin-independent phase. The research will focus on the role of UL9 as a switch factor from the first to the second phase and characterise in depth the conditions of UL9 binding to the origin of replication.
Fields of science
Programme(s)
Funding Scheme
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
Coordinator
SW7 2AZ London
United Kingdom
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