Molecular events in herpes simplex virus type 1 replication
Herpes simplex virus type 1 (HSV-1) is a widespread pathogen. However, the regulation of its genome replication is not well understood. The current model of HSV-1 genome replication includes an origin-dependent phase followed by an origin-independent phase. Funded by the Marie Skłodowska-Curie Actions programme, the HSV1_Single_Molecule project aims to elucidate molecular events of the less studied origin-independent replication phase using single-molecule imaging techniques. Previously, it was found that the HSV-1 origin binding protein UL9 is necessary for the origin-dependent but dispensable or inhibitory in the origin-independent phase. The research will focus on the role of UL9 as a switch factor from the first to the second phase and characterise in depth the conditions of UL9 binding to the origin of replication.
Fields of science
Call for proposalSee other projects for this call
Funding SchemeMSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
SW7 2AZ London
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