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Implications of tissue stiffness in growth control during limb regeneration in salamanders (Ambystoma mexicanum)

Project description

Proximity and tissue regeneration capacity

Intriguingly, amputated structures that are far from the torso tend to regenerate at a slower pace compared to structures that are closer to the torso. A differential gradient of cell surface molecules, and hence intercellular adhesions, has been proposed as the main reason behind this observation. The EU-funded ProxDistReg project aims to investigate the biomechanical properties of tissues and how they affect regeneration. Researchers will employ the salamander species Axolotl mexicanum as a model organism and undertake an extensive analysis of amputated limbs at the cell biology, physiology, and gene expression levels. The work will provide important information on tissue regeneration and assist in the future design of biomaterials.


Net EU contribution
€ 174 806,40
Helmholtzstrasse 10
01069 Dresden

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Sachsen Dresden Dresden, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00