Advanced study into the mechanisms of transcriptional memory
Transcriptional memory is a phenomenon during which cells primed with particular stimuli show increased gene expression after re-stimulation at a later time. Such memory of gene expression states is essential for the development and maintenance of tissues. Funded by the Marie Skłodowska-Curie Actions programme, the IMMUNE-GENEMEMO project is based on the discovery of genes with a strong transcriptional memory of prior interferon-gamma (IFNγ) activation, creating a larger proportion of cells expressing the target gene. The project aims to identify novel transcriptional memory maintenance factors in human cells using an efficient high-throughput cell sorting strategy combined with genome-wide CRISPR-Cas9 mutagenesis protocols, and establish the role of these components in the stability of dendritic cell identity.
Fields of science
Funding SchemeMSCA-IF-GF - Global Fellowships
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
02114 Boston Ma
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