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Mechanisms of Cell Extrusion controlling Tissue Homeostasis in the Intestine

Project description

The role of tissue mechanics in homeostasis

The epithelium lining the intestine is one of the fastest-regenerating tissues in the body. However, it is not fully clear what triggers differentiated cells to be removed from the intestinal epithelium. The scope of the EU-funded MCExtrusion project is to elucidate the underlying mechanisms and identify molecular determinants of cell extrusion. Researchers will also study the mechanical properties of the intestinal epithelium and investigate the role of tissue mechanics such as tension and contractility in the process of cell extrusion. Results will offer genetic and mechanistic insight into homeostasis of the intestine, with obvious projections in health and disease.

Coordinator

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Net EU contribution
€ 187 572,48
Address
Kloveniersburgwal 29 Het Trippenhuis
1011 JV Amsterdam
Netherlands

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Other
Other funding
€ 187 572,48