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Psychiatric Ratings using Intermediate Stratified Markers 2

Objective

The current nosology of neuropsychiatric disorders provides a pragmatic approach to diagnosis and treatment choice but lacks reference to quantitative biological underpinnings of disease. This weakness impedes innovative drug development. To test whether a quantitative biological approach to the understanding and classification of neuropsychiatric disorders is both feasible and useful the PRISM 1 consortium was formed by academics, SMEs, patient organizations, regulators, ECNP, and EFPIA partners. PRISM 1 has now successfully identified quantitative biological parameters related to diagnosis (Schizophrenia (SZ) and Alzheimer Disease (AD)) as well as to social functioning irrespective of diagnosis. From the relationships between social function, neuroimaging, and cognitive endpoints a new neurobiological framework has emerged now needing further validation. Genetic studies of social functioning outcomes revealed known and novel loci for this phenotype. In addition, a preclinical test battery was developed, based on homologs of the clinical paradigms, to allow effective back-translation and a deepening of our neurobiological knowledge. Finally, a novel digital tool for assessing social function provided a novel, objective characterization that transcended the initial diagnostic classification and the digital readouts were associated with other study parameters. To build on outcomes of PRISM 1, PRISM 2 has three objectives. First, to determine the reproducibility of the transdiagnostic and pathophysiological relationship between DMN integrity and social dysfunction in SZ and AD that emerged from PRISM 1 and determine its potential to generalise to Major Depressive Disorders. Second, to test the causality between the quantitative variation in DMN integrity and social dysfunction. Third, to translate and communicate project results to the benefit of stakeholders, such as regulators, patients and their families, and health care providers.

Call for proposal

H2020-JTI-IMI2-2020-22-single-stage
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Coordinator

RIJKSUNIVERSITEIT GRONINGEN
Address
Broerstraat 5
9712CP Groningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 028 125

Participants (13)

P1VITAL LIMITED
United Kingdom
EU contribution
€ 1 036 245
Address
Manor House Howbery Park
OX10 8BA Wallingford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
EU contribution
€ 25 000
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen
Activity type
Higher or Secondary Education Establishments
CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain
EU contribution
€ 499 976,25
Address
Calle Monforte De Lemos 5
28029 Madrid
Activity type
Research Organisations
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 25 000
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
STICHTING VUMC
Netherlands
EU contribution
€ 436 870
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
BIOTRIAL
France
EU contribution
€ 174 690
Address
Rue Jean-louis Bertrand 7 - 9
35042 Rennes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SBGNEURO LTD
United Kingdom
EU contribution
€ 175 000
Address
6A St Andrews Court Wellington Str
OX9 3WT Thame
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Concentris Research Management GmbH
Germany
EU contribution
€ 260 000
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU contribution
€ 270 000
Address
Albinusdreef 2
2333 ZA Leiden
Activity type
Higher or Secondary Education Establishments
STICHTING BURO ECNP
Netherlands
EU contribution
€ 50 000
Address
Daltonlaan 400
3584 BK Utrecht
Activity type
Other
COHEN VETERANS BIOSCIENCE INC
United States
EU contribution
€ 0
Address
One Broadway, 14Th Floor
02142 Cambridge Ma
Activity type
Research Organisations
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
EU contribution
€ 0
Address
Binger Strasse
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PSYCHOGENICS INC
United States
EU contribution
€ 0
Address
765 Old Saw Mill River Road
NY10591 Tarrytown
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)