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Inter-tissue communication during nematode infections: role of dermal γδ17 T cells

Project description

Inter-tissue coordination of immune responses during helminth infections

Effective pathogen elimination has to include prevention from excessive collateral damage and requires the coordination of different types of immune responses within particular tissues. Reaching such equilibrium requires very complex coordination in cases of pathogens that migrate across different organs and tissues. The mechanism of coordination of immune responses between tissues is largely unexplored. Helminth infections provide unique models to investigate this process in cases when invasive larvae migrate across different organs to complete their life cycles. Funded by the Marie Skłodowska-Curie Actions programme, the INTERCONNECTION project will use nematode parasites, Nippostrongylus brasiliensis and Litomosoides sigmodontis, to investigate the coordination of the immune responses between different non-lymphoid tissues.

Coordinator

THE UNIVERSITY OF MANCHESTER
Net EU contribution
€ 212 933,76
Address
Oxford Road
M13 9PL Manchester
United Kingdom

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Region
North West (England) Greater Manchester Manchester
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00