Project description
Investigation of neuronal transplantation at the individual cell level
Neuronal death is a contributing factor to the neuronal loss in chronic neurodegeneration and dementia, such as amyotrophic lateral sclerosis and Alzheimer’s disease, and also in cases of cerebral ischemia and traumatic brain injury. Attempts to replace the lost neurons by transplantation look promising and attractive from a medical perspective but require a significantly better understanding of transplants’ integration and interaction with the host environment. Funded by the Marie Skłodowska Curie Actions programme, the NeurTransHet project will employ single-cell transcriptomics technology and high-resolution imaging to investigate the individual cell contribution, the effect of transplant heterogeneity, and the interaction of the transplanted cells with the environment in a mouse model of human neuronal transplantation.
Fields of science
- medical and health sciencesmedical biotechnologygenetic engineering
- natural sciencesbiological sciencescell biology
- natural sciencesbiological sciencesgeneticsRNA
- medical and health sciencesclinical medicinetransplantation
- medical and health sciencesmedical biotechnologycells technologies
- natural sciencesbiological sciencesgeneticsgenomeseukaryotic genomes
Programme(s)
Funding Scheme
MSCA-IF-EF-ST - Standard EF
Coordinator
80539 Muenchen
Germany
See on map