Mechanistic insight into transcription factor target localisation
Gene transcription into messenger RNA requires the concerted action of transcription factors (TFs), proteins with DNA-binding domains that can bind to specific DNA sequences. Given the size and complexity of the genome and the small binding motif of TFs, it is puzzling how they find the correct sites. The working hypothesis of the EU-funded bInDR project is that specific regions within TFs known as long intrinsically disordered regions (IDRs) play a key role in TF specificity. Researchers will investigate the IDR-based molecular mechanism and generate a model of how TFs recognise their in vivo targets with great efficiency and specificity.
Fields of science
Funding SchemeERC-ADG - Advanced Grant
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