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DNA binding specificity in-vivo

Project description

Mechanistic insight into transcription factor target localisation

Gene transcription into messenger RNA requires the concerted action of transcription factors (TFs), proteins with DNA-binding domains that can bind to specific DNA sequences. Given the size and complexity of the genome and the small binding motif of TFs, it is puzzling how they find the correct sites. The working hypothesis of the EU-funded bInDR project is that specific regions within TFs known as long intrinsically disordered regions (IDRs) play a key role in TF specificity. Researchers will investigate the IDR-based molecular mechanism and generate a model of how TFs recognise their in vivo targets with great efficiency and specificity. 

Host institution

WEIZMANN INSTITUTE OF SCIENCE
Net EU contribution
€ 2 500 000,00
Address
Herzl Street 234
7610001 Rehovot
Israel

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Beneficiaries (1)

WEIZMANN INSTITUTE OF SCIENCE
Israel
Net EU contribution
€ 2 500 000,00
Address
Herzl Street 234
7610001 Rehovot

See on map

Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00