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Bone healing mechanomics in a mouse model of accelerated aging.

Project description

Mechanistic insight into bone repair

Bone healing after a fracture begins with localised inflammation followed by bone regrowth and remodelling. The process responds to mechanical stimulation, but the underlying molecular mechanisms remain poorly understood. Moreover, this response to mechanical stimulation may decline with age. The EU-funded project, MechanoHealing, will delineate the mechanobiology of bone healing by studying how individual bone cells translate mechanical stimuli into repair. The project will employ a multi-disciplinary approach to profile individual cells, the mechanical environment at the fracture site and the nanostructure of the newly formed bone. Results will lead to a better understanding of the age-associated decline in bone repair and to targeted intervention therapies against cases where healing is delayed or fails.


Net EU contribution
€ 191 149,44
Raemistrasse 101
8092 Zuerich

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Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00