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Real World Handling of Protein Drugs - Exploration, Evaluation and Education

Objective

RealHOPE will create an understanding of the real-life handling of protein drugs in hospital pharmacy, clinics and in the hands of patients by applying smart tag technologies. Different parameters will be logged and combined with protein characterisation at different stages, as well as with information from EFPIA partners on their drugs in use. Statistical evaluation of the data will be used to identify patterns in handling that are linked to protein destabilisation occurrence and type of protein degradation. Focus interviews with personnel in hospital pharmacies, clinics and with patients/care givers will be used to understand current handling practice and what the desired handling instructions and limitations are. These insights will be used to design in-use mimicking stability protocols for the protein drugs in the project. Ultra-scaled-down devices for stability assessment will be designed to be used in early phase for efficient development cost effective and safe future protein therapies. Protocols and devices will be validated towards the collected handling data base. Interventions in hospital pharmacies using e.g. compounding robots will be investigated. Techniques to assess e.g. aggregate formation in the final drug preparation situation will be evaluated together with SMEs producing analytical tools and hospital pharmacists. The collected data and interviews will form the base of development of teaching materials directed towards different target groups: hospital pharmacists, nurses and patients/care givers. App developers will be active in this part to design attractive and efficient apps for teaching and collecting therapy performance data.

Call for proposal

H2020-JTI-IMI2-2020-20-two-stage
See other projects for this call

Coordinator

LUNDS UNIVERSITET
Address
Paradisgatan 5C
22100 Lund
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 560 472,50

Participants (23)

CENTRE FOR PROCESS INNOVATION LIMITED LBG
United Kingdom
EU contribution
€ 456 035,25
Address
Wilton Centre Wilton
TS10 4RF Redcar Cleveland
Activity type
Research Organisations
RISE RESEARCH INSTITUTES OF SWEDEN AB
Sweden
EU contribution
€ 618 203,50
Address
Brinellgatan 4
501 15 Boras
Activity type
Research Organisations
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 514 968,75
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 325 348,75
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 272 500
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
REGION UPPSALA
Sweden
EU contribution
€ 130 445
Address
Po Box 602
751 25 Uppsala
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 40 000
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
AZIENDA OSPEDALIERA UNIVERSITARIA INTEGRATA 'ISTITUTI OSPITALIERI DI VERONA
Italy
EU contribution
€ 15 285
Address
Piazzale Aristide Stefani 1
37126 Verona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SOCIETA ITALIANA DI FARMACIA CLINICA E TERAPIA
Italy
EU contribution
€ 17 250
Address
Via Carlo Farini 81
20159 Milano
Activity type
Other
REUMATIKERFORBUNDET
Sweden
EU contribution
€ 12 500
Address
Halsingegatan 43, 10Tr
113 31 Stockholm
Activity type
Other
PROBATION LABS SWEDEN AB
Sweden
EU contribution
€ 41 347,50
Address
Vikbogatan 8
212 32 Malmo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELSA SCIENCE AB
Sweden
EU contribution
€ 104 500
Address
Vastmannagatan 4
111 24 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AZIENDA ULSS N3 SERENISSIMA
Italy
EU contribution
€ 16 250
Address
Via Don Tosatto 147
30174 Venezia Mestre
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
PLURIMA SPA
Italy
EU contribution
€ 14 877,50
Address
Piazza Santo Stefano 6
20122 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ABBVIE INC
United States
EU contribution
€ 0
Address
North Waukegan Road 1
60064 North Chicago Il
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASTRAZENECA AB
Sweden
EU contribution
€ 0
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
EU contribution
€ 0
Address
Binger Strasse
55218 Ingelheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LONZA AG
Switzerland
EU contribution
€ 0
Address
Muenchensteinerstrasse 38
4002 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN
Germany
EU contribution
€ 0
Address
Frankfurter Strasse 250
64293 Darmstadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PFIZER LIMITED
United Kingdom
EU contribution
€ 0
Address
Ramsgate Road
CT13 9NJ Sandwich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
F. HOFFMANN-LA ROCHE AG
Switzerland
EU contribution
€ 0
Address
Grenzacherstrasse 124
4070 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SANOFI-AVENTIS DEUTSCHLAND GMBH
Germany
EU contribution
€ 0
Address
Bruningstrasse 50
65929 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TEVA PHARMACEUTICAL INDUSTRIES LIMITED
Israel
EU contribution
€ 0
Address
5 Basel St
49131 Petach Tivka
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)