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Life-long cross-generational priming of the hypothalamus for obesity

Project description

Maternal obesity as a potential cause of permanent changes in offspring's hypothalamic neurons

Clinical and experimental studies show a correlation between obesity during pregnancy and congenital metabolic illnesses. Understanding the connection between maternal obesity and metabolic control deficits in the offspring requires an investigation of the hypothalamus as the neuroendocrine interface. The EU-funded FOODFORLIFE project is testing the hypothesis that maternal obesity causes permanent molecular changes in the offspring's hypothalamic neurons, damaging their plasticity and adaptive repertoire. The approach involves single-cell sequencing to discover permanent modifications to gene expression at the successive developmental stages in mouse models. The objective is to identify molecular, cellular and network-level changes in the hypothalamus of offspring born to obese mothers and to understand the life-long consequences of metabolic programming of the developing brain.

Host institution

MEDIZINISCHE UNIVERSITAET WIEN
Net EU contribution
€ 2 498 960,00
Address
Spitalgasse 23
1090 Wien
Austria

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 498 960,00

Beneficiaries (1)

MEDIZINISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 2 498 960,00
Address
Spitalgasse 23
1090 Wien

See on map

Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Other funding
€ 2 498 960,00